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    EMP46 Emp46p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850769, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EMP46
    Official Full Name
    Emp46p
    Primary source
    SGD:S000004070
    Locus tag
    YLR080W
    See related
    AllianceGenome:SGD:S000004070; FungiDB:YLR080W; VEuPathDB:YLR080W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables carbohydrate binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in COPII-coated ER to Golgi transport vesicle and Golgi membrane. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to human LMAN1 (lectin, mannose binding 1) and LMAN1L (lectin, mannose binding 1 like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See EMP46 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (287916..289250)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Bos1p Neighboring gene cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 Neighboring gene galactose permease GAL2 Neighboring gene Srl2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oligomerization of a cargo receptor directs protein sorting into COPII-coated transport vesicles. Sato K, et al. Mol Biol Cell, 2003 Jul. PMID 12857885, Free PMC Article
    2. Modification of the pH Dependence of Assembly of Yeast Cargo Receptor Emp47p Coiled-Coil Domains: Computational Design and Experimental Mutagenesis. Kato K, et al. J Phys Chem B, 2021 Mar 11. PMID 33646773
    3. Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p. Satoh T, et al. J Biol Chem, 2006 Apr 14. PMID 16439369
    4. pH-Dependent Assembly and Segregation of the Coiled-Coil Segments of Yeast Putative Cargo Receptors Emp46p and Emp47p. Ishii K, et al. PLoS One, 2015. PMID 26447473, Free PMC Article
    5. The assembly mechanism of coiled-coil domains of the yeast cargo receptors Emp46p/47p and the mutational alteration of pH-dependency of complex formation. Kato K, et al. J Biochem, 2018 May 1. PMID 29361014

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular interactions of the coiled-coil segments of Emp46p and Emp47p.
      Title: pH-Dependent Assembly and Segregation of the Coiled-Coil Segments of Yeast Putative Cargo Receptors Emp46p and Emp47p.
    2. analysis of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p
      Title: Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emp46p
    NP_013181.1
    • Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      287916..289250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181967.1 → NP_013181.1  TPA: Emp46p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013181.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY80, Q12396
      UniProtKB/TrEMBL
      A7A0Y4, B3LT48, B5VN12, C7GQQ4, G2WIS1, N1NZJ0
      Conserved Domains (1) summary
      cd06903
      Location:56 → 270
      lectin_EMP46_EMP47; EMP46 and EMP47 type 1 transmembrane proteins, N-terminal lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12396.1

    Gene LinkOut

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