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    LDB18 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850677, updated on 22-Aug-2024

    Summary

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    Official Symbol
    LDB18
    Primary source
    FungiDB:YLL049W
    Locus tag
    YLL049W
    See related
    SGD:S000003972; AllianceGenome:SGD:S000003972; VEuPathDB:YLL049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in establishment of mitotic spindle orientation. Part of dynactin complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (40666..41205)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative ferric-chelate reductase Neighboring gene cofilin Neighboring gene bile acid-transporting ATPase YBT1 Neighboring gene Rnp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides. Corbacho I, et al. Fungal Genet Biol, 2005 Sep. PMID 15993632
    2. Dynein-driven mitotic spindle positioning restricted to anaphase by She1p inhibition of dynactin recruitment. Woodruff JB, et al. Mol Biol Cell, 2009 Jul. PMID 19403691, Free PMC Article
    3. Constitutive dynein activity in She1 mutants reveals differences in microtubule attachment at the yeast spindle pole body. Bergman ZJ, et al. Mol Biol Cell, 2012 Jun. PMID 22535527, Free PMC Article
    4. Functional analysis of eight open reading frames on chromosomes XII and XIV of Saccharomyces cerevisiae. Ahmed Khan S, et al. Yeast, 2000 Dec. PMID 11113969
    5. An array of nuclear microtubules reorganizes the budding yeast nucleus during quiescence. Laporte D, et al. J Cell Biol, 2013 Nov 25. PMID 24247429, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ldb18p
    NP_013051.1
    • Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      40666..41205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181869.1 → NP_013051.1  TPA: Ldb18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXV9, Q07887
      UniProtKB/TrEMBL
      B3LTC7, B5VMQ2, C7GNE6, C8ZCS6, N1P116
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07887.1

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