PTR2 Ptr2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PTR2
Gene description: Ptr2p
Primary source: FungiDB:YKR093W
Locus tag: YKR093W
See related: SGD:S000001801; AllianceGenome:SGD:S000001801; VEuPathDB:YKR093W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables dipeptide transmembrane transporter activity and tripeptide transmembrane transporter activity. Involved in dipeptide transport and tripeptide transport. Located in plasma membrane. Orthologous to several human genes including SLC15A3 (solute carrier family 15 member 3) and SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PTR2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (615730..617535)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

some mutants of Ptr2 that are dysfunctional in dipeptide uptake were still competent to transport BlaS. Mouse-derived oligopeptide transporter PepT1 conferred BlaS sensitivity in the S. cerevisiae ptr2 mutant
Title: Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S.
Ptr2 mutants of the peptide-binding site exhibited severe defects in peptide import and were subject to Rsp5-dependent degradation suggesting that Ptr2 undergoes quality control that renders Ptr2 subject to efficient ubiquitination and degradation.
Title: Functional implications and ubiquitin-dependent degradation of the peptide transporter Ptr2 in Saccharomyces cerevisiae.
The substrate multispecificity of PTR2 indicates that it has an important role in the preferential uptake of vital amino acids.
Title: Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library.
These studies highlight the complementary activities of two dipeptide transport systems under different regulatory controls in common laboratory yeast strains.
Title: Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables tripeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables tripeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oligopeptide transport	IEA Inferred from Electronic Annotation more info
involved_in peptide transport	IEA Inferred from Electronic Annotation more info
involved_in peptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tripeptide transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ptr2p

NP_013019.1

Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by N-end rule pathway via repression by Cup9p; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

615730..617535

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179883.1 → NP_013019.1 TPA: Ptr2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013019.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXF3, P32901

UniProtKB/TrEMBL

A0A8H4C0N8, A7A052, N1P107

Conserved Domains (1) summary

cd17350
Location:79 → 554

MFS_PTR2; Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters