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    MDM35 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853812, updated on 22-Aug-2024

    Summary

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    Official Symbol
    MDM35
    Primary source
    FungiDB:YKL053C-A
    Locus tag
    YKL053C-A
    See related
    SGD:S000007243; AllianceGenome:SGD:S000007243; VEuPathDB:YKL053C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial respiratory chain complex assembly and phospholipid translocation. Located in mitochondrial intermembrane space. Used to study breast cancer. Orthologous to human TRIAP1 (TP53 regulated inhibitor of apoptosis 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (339182..339442, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Ask1p Neighboring gene Sfk1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of mitochondrial phosphatidate transfer by Ups1. Lu J, et al. Commun Biol, 2020 Aug 25. PMID 32843686, Free PMC Article
    2. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. Yu F, et al. EMBO Rep, 2015 Jul. PMID 26071601, Free PMC Article
    3. Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance. Adams C, et al. Oncol Rep, 2015 Jul. PMID 25998939
    4. Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria. Miyata N, et al. J Cell Biol, 2016 Jul 4. PMID 27354379, Free PMC Article
    5. Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria. Watanabe Y, et al. Nat Commun, 2015 Aug 3. PMID 26235513, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal structure of Ups1-Mdm35 bound with a phosphatidic acid (PA) molecule at 2.0 A resolution; study reveals molecular basis of Ups1-Mdm35-mediated PA binding and transfer and sheds new light on mechanism of intramitochondrial lipid transport by MSF1/PRELI family proteins
      Title: Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.
    2. The Ups1-Mdm35 complex constitutes a single domain that has a deep pocket and flexible Omega-loop lid. A basic residue at the pocket bottom and the Omega-loop lid are important for phosphatidic acid extraction from the membrane following Ups1 binding.
      Title: Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.
    3. The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
      Title: Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
    4. The authors identified Mdm35, a member of the twin Cx9C protein family, as a novel interaction partner of Ups1 and Ups2.
      Title: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
    5. Loss of Mdm35, Emi1, and Mrp10 leads to abnormal mitochondrial morphology
      Title: Systematic analysis of the twin cx(9)c protein family.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    contributes_to phosphatidic acid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mdm35p
    NP_012870.1
    • Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      339182..339442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184336.1 → NP_012870.1  TPA: Mdm35p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012870.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN4, O60200, Q6Q599
      UniProtKB/TrEMBL
      A6ZZR3, B3LR37, C7GP21, C8ZCB8, G2WHX9, N1P099
      Conserved Domains (1) summary
      pfam05254
      Location:7 → 75
      UPF0203; Uncharacterized protein family (UPF0203)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60200.3

    Gene LinkOut

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