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    ASK1 Ask1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853814, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ASK1
    Official Full Name
    Ask1p
    Primary source
    SGD:S000001535
    Locus tag
    YKL052C
    See related
    AllianceGenome:SGD:S000001535; FungiDB:YKL052C; VEuPathDB:YKL052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in positive regulation of attachment of spindle microtubules to kinetochore and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ASK1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (339668..340546, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Mdm35p Neighboring gene Sfk1p Neighboring gene Lpx2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control. Weiβ M, et al. Cell Rep, 2023 Feb 28. PMID 36701236, Free PMC Article
    2. The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs. Thompson MK, et al. Elife, 2016 Apr 27. PMID 27117520, Free PMC Article
    3. The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae. Li Y, et al. Cell Cycle, 2003 Mar-Apr. PMID 12695666
    4. Three interacting regions of the Ndc80 and Dam1 complexes support microtubule tip-coupling under load. Flores RL, et al. J Cell Biol, 2022 May 2. PMID 35353161, Free PMC Article
    5. Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes. Lampert F, et al. J Cell Biol, 2013 Jan 7. PMID 23277429, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
      Title: Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control.
    2. Together these results reveal a role for Asc1/RACK1 in a length-dependent initiation mechanism optimized for efficient translation of genes with important housekeeping functions.
      Title: The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs.
    3. Results describe two novel subunits of DASH, Hsk2 and Hsk3 (helper of Ask1), and suggest that Hsk3 acts to incorporate Ask1 into the DASH complex.
      Title: Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ask1p
    NP_012872.2
    • Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      339668..340546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179618.1 → NP_012872.2  TPA: Ask1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012872.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXN5, P35734, Q68EC3, Q6B290
      UniProtKB/TrEMBL
      C7GP22, N1NZ83
      Conserved Domains (1) summary
      pfam08655
      Location:10 → 73
      DASH_Ask1; DASH complex subunit Ask1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35734.2

    Gene LinkOut

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