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    PSG1 Psg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853785, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PSG1
    Official Full Name
    Psg1p
    Primary source
    SGD:S000001560
    Locus tag
    YKL077W
    See related
    AllianceGenome:SGD:S000001560; FungiDB:YKL077W; VEuPathDB:YKL077W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein maturation and protein targeting. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PSG1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (291453..292631)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Smy1p Neighboring gene RNA helicase Neighboring gene Aan1p Neighboring gene Mud2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. Shim JS, et al. J Natl Cancer Inst, 2012 Oct 17. PMID 23042933, Free PMC Article
    2. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article
    3. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    4. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article
    5. Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Freije BJ, et al. Chem Res Toxicol, 2022 Feb 21. PMID 35084835, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ykl077w (Psg1) physically interacts with Exp1 and can be found in the Golgi and COPI vesicles but does not directly bind Pma1.
      Title: Two novel effectors of trafficking and maturation of the yeast plasma membrane H(+) -ATPase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Psg1p
    NP_012846.1
    • Protein that promotes the transport and maturation of Pma1 with Exp1; cleaved specifically by Kex2p; localizes to the Golgi apparatus and to the endoplasmic reticulum in HTP studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      291453..292631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179643.1 → NP_012846.1  TPA: Psg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXL0, P36081
      UniProtKB/TrEMBL
      A6ZZN9, B3LR14, B5VM79, C7GVN1, C8ZC96, G2WHV5, N1P2A8
      Conserved Domains (1) summary
      pfam14610
      Location:143 → 325
      DUF4448; Protein of unknown function (DUF4448)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36081.1

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