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    JEN1 monocarboxylate/H+ symporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853663, updated on 18-Sep-2024

    Summary

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    Official Symbol
    JEN1
    Official Full Name
    monocarboxylate/H+ symporter
    Primary source
    SGD:S000001700
    Locus tag
    YKL217W
    See related
    AllianceGenome:SGD:S000001700; FungiDB:YKL217W; VEuPathDB:YKL217W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables secondary active monocarboxylate transmembrane transporter activity and selenite:proton symporter activity. Involved in plasma membrane lactate transport; plasma membrane pyruvate transport; and plasma membrane selenite transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See JEN1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (22234..24084)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Cos9p Neighboring gene threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 Neighboring gene dihydroorotate dehydrogenase Neighboring gene 5-oxoprolinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improvement of ethanol production from D-lactic acid by constitutive expression of lactate transporter Jen1p in Saccharomyces cerevisiae. Wakamatsu M, et al. Biosci Biotechnol Biochem, 2013. PMID 23649240
    2. A substrate translocation trajectory in a cytoplasm-facing topological model of the monocarboxylate/H⁺ symporter Jen1p. Soares-Silva I, et al. Mol Microbiol, 2011 Aug. PMID 21651629
    3. Jen1p: a high affinity selenite transporter in yeast. McDermott JR, et al. Mol Biol Cell, 2010 Nov 15. PMID 20861301, Free PMC Article
    4. The conserved sequence NXX[S/T]HX[S/T]QDXXXT of the lactate/pyruvate:H(+) symporter subfamily defines the function of the substrate translocation pathway. Soares-Silva I, et al. Mol Membr Biol, 2007 Sep-Dec. PMID 17710650
    5. Multiple transcripts regulate glucose-triggered mRNA decay of the lactate transporter JEN1 from Saccharomyces cerevisiae. Andrade RP, et al. Biochem Biophys Res Commun, 2005 Jun 24. PMID 15896325

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Saccharomyces cerevisiae can use two transport mechanisms to import lactic acid: a 'saturable' component of the transport, which requires the presence of a functional Jen1p transporter, and a Jen1p independent 'non-saturable' component.
      Title: The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies.
    2. study demonstrated that monocarboxylate transporters Jen1 and Ady2 are modulators of lactic acid production
      Title: Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.
    3. Data show that overexpression of Jen1p enables selenite accumulation in yeast compared with a JEN1 knock out strain.
      Title: Jen1p: a high affinity selenite transporter in yeast.
    4. Data show that casein kinase 1-dependent phosphorylation and HECT-ubiquitin ligase Rsp5-dependent ubiquitylation are required for Jen1 endocytosis.
      Title: Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of lysine 63-linked ubiquitin chains.
    5. The presence of the JEN1(+391) transcript correlated with rapid glucose-triggered mRNA degradation of the JEN1(-51) transcript, whereas when the small transcript started at position +972, the JEN1(-51) mRNA turnover rate was unaffected.
      Title: Multiple transcripts regulate glucose-triggered mRNA decay of the lactate transporter JEN1 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables organic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables selenite:proton symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sialic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane lactate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane lactate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane pyruvate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane selenite transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monocarboxylate/H+ symporter
    NP_012705.1
    • Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      22234..24084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179782.1 → NP_012705.1  TPA: monocarboxylate/H+ symporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWY6, P36035
      UniProtKB/TrEMBL
      B3LQP2, B5VLU8, C7GIZ6, G2WHH7, N1P0Q3
      Conserved Domains (1) summary
      TIGR00891
      Location:129 → 544
      2A0112; putative sialic acid transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36035.1

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