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    LAS21 mannose-ethanolamine phosphotransferase LAS21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853384, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LAS21
    Official Full Name
    mannose-ethanolamine phosphotransferase LAS21
    Primary source
    SGD:S000003598
    Locus tag
    YJL062W
    See related
    AllianceGenome:SGD:S000003598; FungiDB:YJL062W; VEuPathDB:YJL062W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GPI7
    Summary
    Enables CP2 mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane and plasma membrane. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See LAS21 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (317284..319776)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL8 Neighboring gene Coa3p Neighboring gene linker nucleoporin NUP82 Neighboring gene kynurenine--oxoglutarate transaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GPI7 affects cell-wall protein anchorage in Saccharomyces cerevisiae and Candida albicans. Richard M, et al. Microbiology (Reading), 2002 Jul. PMID 12101300
    2. Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. Benachour A, et al. J Biol Chem, 1999 May 21. PMID 10329735
    3. [Biosynthetic pathway of GPI-anchored cell wall mannoproteins in yeast as a potential target for anti-fungal and anti-cancer drugs]. Jigami Y. Nihon Ishinkin Gakkai Zasshi, 2008. PMID 19001750
    4. COPII coat composition is actively regulated by luminal cargo maturation. Manzano-Lopez J, et al. Curr Biol, 2015 Jan 19. PMID 25557665
    5. Identification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae. Benghezal M, et al. J Cell Biol, 1995 Sep. PMID 7559756, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. isolated gpi7 mutants, which have defects in cell separation and a daughter cell-specific growth defect at the non-permissive temperature
      Title: GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables CP2 mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CP2 mannose-ethanolamine phosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organophosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannose-ethanolamine phosphotransferase LAS21
    NP_012473.1
    • Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor; integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      317284..319776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181495.1 → NP_012473.1  TPA: mannose-ethanolamine phosphotransferase LAS21 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWC0, P40367
      UniProtKB/TrEMBL
      B3LQ48, B5VLB4, C7GR50, C8ZBF2, N1P0V3
      Conserved Domains (2) summary
      COG1524
      Location:18 → 610
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      cd16024
      Location:48 → 343
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40367.1

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