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    LINC00703 long intergenic non-protein coding RNA 703 [ Homo sapiens (human) ]

    Gene ID: 100507059, updated on 22-Oct-2024

    Summary

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    Official Symbol
    LINC00703provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 703provided by HGNC
    Primary source
    HGNC:HGNC:44677
    See related
    Ensembl:ENSG00000224382 AllianceGenome:HGNC:44677
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00703 in Genome Data Viewer
    Location:
    10p15.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (4384246..4410612)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (4386834..4413184)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (4426438..4452804)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376370 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:4386271-4387470 Neighboring gene Sharpr-MPRA regulatory region 6674 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:4395214-4396413 Neighboring gene uncharacterized LOC105376371 Neighboring gene uncharacterized LOC105376372 Neighboring gene Sharpr-MPRA regulatory region 7156 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:4449652-4450851 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:4473152-4474351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2922 Neighboring gene RNA, U6 small nuclear 163, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:4599913-4600414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:4649568-4650068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:4703529-4704512 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:4704879-4706078 Neighboring gene long intergenic non-protein coding RNA 705 Neighboring gene mitotically associated long non coding RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer. Yang H, et al. J Gastric Cancer, 2019 Dec. PMID 31897348, Free PMC Article
    2. Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression. Sun HB, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32572878
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression.
      Title: Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_108054.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK095699, DA500285

    2. NR_108055.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK095699
      Related
      ENST00000454152.2

    3. NR_108056.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and contains an alternate 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK095699, BX095585
      Related
      ENST00000655424.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      4384246..4410612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      4386834..4413184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials