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    WBP1L WW domain binding protein 1 like [ Homo sapiens (human) ]

    Gene ID: 54838, updated on 14-Nov-2024

    Summary

    Official Symbol
    WBP1Lprovided by HGNC
    Official Full Name
    WW domain binding protein 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:23510
    See related
    Ensembl:ENSG00000166272 MIM:611129; AllianceGenome:HGNC:23510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OPA1L; OPAL1; C10orf26
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to act upstream of or within CXCL12-activated CXCR4 signaling pathway; hemopoiesis; and positive regulation of protein ubiquitination. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.1), adrenal (RPKM 15.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WBP1L in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102743948..102816262)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103629750..103702045)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104503705..104576019)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104433562-104434111 Neighboring gene ARF like GTPase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104474219-104474795 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104474796-104475371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104488530-104489304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104489305-104490077 Neighboring gene sideroflexin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104534833-104535364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104535897-104536428 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:104536429-104536960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104540708-104541208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104541209-104541709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3950 Neighboring gene RNA, U6 small nuclear 1231, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104575177-104575710 Neighboring gene CYP17A1 antisense RNA 1 Neighboring gene CYP17A1 promoter Neighboring gene cytochrome P450 family 17 subfamily A member 1 Neighboring gene profilin 1 pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ20154, FLJ20367, MGC125648

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in CXCL12-activated CXCR4 signaling pathway  
    involved_in hemopoiesis  
    involved_in positive regulation of protein ubiquitination  
    Component Evidence Code Pubs
    located_in membrane  

    General protein information

    Preferred Names
    WW domain binding protein 1-like
    Names
    outcome predictor in acute leukemia 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083913.2NP_001077382.1  WW domain binding protein 1-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_001077382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL358790, AL391121, AY656171, CX163170
      Consensus CDS
      CCDS44473.1
      UniProtKB/Swiss-Prot
      Q9NX94
      Related
      ENSP00000414721.1, ENST00000448841.7
      Conserved Domains (2) summary
      pfam11669
      Location:43144
      WBP-1; WW domain-binding protein 1
      PHA03249
      Location:159280
      PHA03249; DNA packaging tegument protein UL25; Provisional
    2. NM_017787.5NP_060257.4  WW domain binding protein 1-like isoform 2

      See identical proteins and their annotated locations for NP_060257.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon at its 5' end, compared to variant 1, resulting in a unique 5' UTR and use of a distinct translation initiation codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AL358790, AY656171, DA797839
      Consensus CDS
      CCDS7540.1
      UniProtKB/Swiss-Prot
      B3KPF4, B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6, Q9NX94
      Related
      ENSP00000358905.4, ENST00000369889.5
      Conserved Domains (2) summary
      pfam11669
      Location:22123
      WBP-1; WW domain-binding protein 1
      PHA03249
      Location:138259
      PHA03249; DNA packaging tegument protein UL25; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      102743948..102816262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539913.3XP_011538215.1  WW domain binding protein 1-like isoform X1

      Conserved Domains (2) summary
      pfam11669
      Location:34135
      WBP-1; WW domain-binding protein 1
      PHA03249
      Location:150271
      PHA03249; DNA packaging tegument protein UL25; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      103629750..103702045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366165.1XP_054222140.1  WW domain binding protein 1-like isoform X1

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