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    SEC6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854742, updated on 22-Aug-2024

    Summary

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    Official Symbol
    SEC6
    Primary source
    FungiDB:YIL068C
    Locus tag
    YIL068C
    See related
    SGD:S000001330; AllianceGenome:SGD:S000001330; VEuPathDB:YIL068C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNARE binding activity. Involved in several processes, including Golgi to plasma membrane transport; exocyst localization; and negative regulation of SNARE complex assembly. Located in cellular bud neck and cellular bud tip. Part of exocyst. Orthologous to several human genes including EXOC3 (exocyst complex component 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SEC6 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (233057..235474, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Mam33p Neighboring gene ribosomal 40S subunit protein S24B Neighboring gene uncharacterized protein Neighboring gene ribonucleotide-diphosphate reductase subunit RNR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles. Sivaram MV, et al. Nat Struct Mol Biol, 2006 Jun. PMID 16699513
    2. Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele. Lamping E, et al. Gene, 2005 Nov 21. PMID 16185821
    3. ATP-dependent transport of organic anions in secretory vesicles of Saccharomyces cerevisiae. St-Pierre MV, et al. Proc Natl Acad Sci U S A, 1994 Sep 27. PMID 7937792, Free PMC Article
    4. Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p. Sivaram MV, et al. Biochemistry, 2005 Apr 26. PMID 15835919
    5. SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Potenza M, et al. Yeast, 1992 Jul. PMID 1523887

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest a new model in which Sec6 promotes SNARE complex assembly, similar to the role proposed for other tether subunit-SNARE interactions
      Title: The Exocyst Subunit Sec6 Interacts with Assembled Exocytic SNARE Complexes.
    2. synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p
      Title: The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p.
    3. upon vesicle arrival, Sec6 is proposed to release Sec9 in favor of Sec6-exocyst assembly and to simultaneously recruit Sec1 to sites of secretion for coordinated SNARE complex formation and membrane fusion.
      Title: Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1.
    4. Sec6p is required to anchor exocyst complexes at sites of secretion.
      Title: Sec6p anchors the assembled exocyst complex at sites of secretion.
    5. residues 300-410 are necessary for dimerization, and the presence of the N-terminal region (1-299) increases dimer stability
      Title: Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p.
    6. Study shows that the single point mutation L633P in the SEC6 coding region defines the sec6-4 mutation phenotype.
      Title: Characterization of the Saccharomyces cerevisiae sec6-4 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of SNARE complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of SNARE complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of SNARE complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    SNARE-binding exocyst subunit SEC6
    NP_012196.1
    • Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; binds to SNARE complexes binteracting with Sec9p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      233057..235474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179418.1 → NP_012196.1  TPA: SNARE-binding exocyst subunit SEC6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVL6, P32844
      UniProtKB/TrEMBL
      A6ZVK5, B3LTS1, C7GVZ2, C8ZAH9, E9P8I5, G2WG80, N1P0Z7
      Conserved Domains (1) summary
      COG5173
      Location:2 → 805
      SEC6; Exocyst complex subunit SEC6 [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32844.2

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