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    SVP26 Svp26p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856587, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SVP26
    Gene description
    Svp26p
    Primary source
    FungiDB:YHR181W
    Locus tag
    YHR181W
    See related
    SGD:S000001224; AllianceGenome:SGD:S000001224; VEuPathDB:YHR181W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ERV26
    Summary
    Enables COPII receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; fungal-type cell wall organization; and protein retention in Golgi apparatus. Acts upstream of or within COPII-coated vesicle cargo loading. Located in COPII-coated ER to Golgi transport vesicle. Is integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Orthologous to human TEX261 (testis expressed 261). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SVP26 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (467228..467914)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene Rgd3p Neighboring gene phosphogluconate dehydrogenase (decarboxylating) GND1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Erv26p directs pro-alkaline phosphatase into endoplasmic reticulum-derived coat protein complex II transport vesicles. Bue CA, et al. Mol Biol Cell, 2006 Nov. PMID 16957051, Free PMC Article
    2. Both Svp26 and Mnn6 are required for the efficient ER exit of Mnn4 in Saccharomyces cerevisiae. Noda Y, et al. J Gen Appl Microbiol, 2019 Dec 19. PMID 30842360
    3. Erv26p-dependent export of alkaline phosphatase from the ER requires lumenal domain recognition. Dancourt J, et al. Traffic, 2009 Aug. PMID 19497047, Free PMC Article
    4. Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae. Tanabe Y, et al. J Gen Appl Microbiol, 2019 Sep 14. PMID 30700649
    5. Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. Bue CA, et al. J Biol Chem, 2009 Sep 4. PMID 19574229, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that Svp26 functions as an ER exit adaptor protein of Mnt2 and Mnt3
      Title: Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae.
    2. Data suggest that Erv26p recognizes sorting information in the lumenal domain of alkaline phosphatase, and that this sorting signal must be positioned near the inner leaflet of the ER membrane for Erv26p-dependent export.
      Title: Erv26p-dependent export of alkaline phosphatase from the ER requires lumenal domain recognition.
    3. Erv26p acts as a protein sorting adaptor for a variety of Type II transmembrane cargo proteins and requires domain-specific interactions with both cargo and coat subunits to promote efficient secretory protein transport.
      Title: Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities.
    4. Erv26p serves as a transmembrane adaptor to link specific secretory cargo to the COPII coat.
      Title: Erv26p directs pro-alkaline phosphatase into endoplasmic reticulum-derived coat protein complex II transport vesicles.
    5. Svp26 has a novel role in retention of a subset of membrane proteins in the early Golgi compartments
      Title: Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables COPII receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables COPII receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables COPII receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables COPII receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COPII-coated vesicle cargo loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein retention in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Svp26p
    NP_012051.3
    • ER exit adaptor for Golgi mannosyltransferases; facilitates the exit of Kre2p, Ktr1p and Mnn4p from the ER; involved in COPII-coated vesicle cargo loading and transport; may also promote the retention of proteins in the early Golgi compartment; integral membrane protein of early Golgi and ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      467228..467914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179312.3 → NP_012051.3  TPA: Svp26p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012051.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLC9, P38869
      UniProtKB/TrEMBL
      A0A6A5PV09, A6ZT87, B3LSU3, B5VKA8, C7GRK3, C8Z9X9, G2WFQ4, N1P4V6
      Conserved Domains (1) summary
      pfam04148
      Location:2 → 205
      Erv26; Transmembrane adaptor Erv26
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38869.1

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