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    CDC23 anaphase promoting complex subunit CDC23 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856571, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CDC23
    Official Full Name
    anaphase promoting complex subunit CDC23
    Primary source
    SGD:S000001209
    Locus tag
    YHR166C
    See related
    AllianceGenome:SGD:S000001209; FungiDB:YHR166C; VEuPathDB:YHR166C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin binding activity. Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and protein ubiquitination. Part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CDC23 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (437170..439050, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 Neighboring gene U4/U6-U5 snRNP complex subunit PRP8 Neighboring gene Thp2p Neighboring gene putative GTPase MTG2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and nucleotide sequence of the CDC23 gene of Saccharomyces cerevisiae. Doi A, et al. Gene, 1990 Jul 2. PMID 2205535
    2. p62cdc23 of Saccharomyces cerevisiae: a nuclear tetratricopeptide repeat protein with two mutable domains. Sikorski RS, et al. Mol Cell Biol, 1993 Feb. PMID 8423787, Free PMC Article
    3. Hydrogen peroxide prolongs mitotic arrest in a dose dependent manner and independently of the spindle assembly checkpoint activity in Saccharomyces cerevisiae. Atalay PB, et al. Acta Biol Hung, 2017 Dec. PMID 29262707
    4. Association of yeast SIN1 with the tetratrico peptide repeats of CDC23. Shpungin S, et al. Proc Natl Acad Sci U S A, 1996 Aug 6. PMID 8710860, Free PMC Article
    5. The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23. Meyn MA 3rd, et al. Arch Biochem Biophys, 2002 Nov 15. PMID 12413490

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit CDC23
    NP_012036.1
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      437170..439050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179297.1 → NP_012036.1  TPA: anaphase promoting complex subunit CDC23 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLB5, P16522
      UniProtKB/TrEMBL
      A6ZT74, B3LST0, B5VK93, C7GJX4, C8Z9W4, G2WFP0, N1P4U4
      Conserved Domains (3) summary
      COG0457
      Location:307 → 561
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:433 → 459
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:12 → 144
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16522.1

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