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    PCT1 choline-phosphate cytidylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853116, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PCT1
    Official Full Name
    choline-phosphate cytidylyltransferase
    Primary source
    SGD:S000003434
    Locus tag
    YGR202C
    See related
    AllianceGenome:SGD:S000003434; FungiDB:YGR202C; VEuPathDB:YGR202C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BSR2; CCT1
    Summary
    Enables choline-phosphate cytidylyltransferase activity. Involved in CDP-choline pathway. Located in nuclear envelope. Part of NLS-dependent protein nuclear import complex. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to several human genes including PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PCT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (903474..904748, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Elongator subunit ELP2 Neighboring gene uncharacterized protein Neighboring gene phosphatase YCH1 Neighboring gene trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of the lipid regulation of yeast and rat CTP: phosphocholine cytidylyltransferase expressed in COS cells. Johnson JE, et al. Biochem J, 1992 Aug 1. PMID 1323275, Free PMC Article
    2. Cessation of growth to prevent cell death due to inhibition of phosphatidylcholine synthesis is impaired at 37 degrees C in Saccharomyces cerevisiae. Howe AG, et al. J Biol Chem, 2002 Nov 15. PMID 12200438
    3. Purification and kinetic characterization of CTP:phosphocholine cytidylyltransferase from Saccharomyces cerevisiae. Friesen JA, et al. Protein Expr Purif, 2001 Feb. PMID 11162399
    4. Expression in Escherichia coli of the Saccharomyces cerevisiae CCT gene encoding cholinephosphate cytidylyltransferase. Tsukagoshi Y, et al. J Bacteriol, 1991 Mar. PMID 1848222, Free PMC Article
    5. Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae. Tsukagoshi Y, et al. Eur J Biochem, 1987 Dec 15. PMID 2826147

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pct1 interacts with Kap60 and Kap95 with this tripartite complex transiting the nuclear pore.
      Title: The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    choline-phosphate cytidylyltransferase
    NP_011718.1
    • Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; controls phosphatidylcholine homeostasis; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      903474..904748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181331.1 → NP_011718.1  TPA: choline-phosphate cytidylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUY4, P13259
      UniProtKB/TrEMBL
      B3LI35, C7GRN4, C8Z994, G2WET0, N1P9Y2
      Conserved Domains (1) summary
      cd02174
      Location:102 → 251
      CCT; CTP:phosphocholine cytidylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13259.2

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