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    OCH1 initiation-specific alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852845, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OCH1
    Official Full Name
    initiation-specific alpha-1,6-mannosyltransferase
    Primary source
    SGD:S000003006
    Locus tag
    YGL038C
    See related
    AllianceGenome:SGD:S000003006; FungiDB:YGL038C; VEuPathDB:YGL038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LDB12; NGD29
    Summary
    Enables alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in Golgi cis cisterna. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See OCH1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (425362..426804, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene carbonyl reductase (NADPH-dependent) Neighboring gene nicotinamidase Neighboring gene Vir1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative functional analysis of the OCH1 mannosyltransferase families in Aspergillus fumigatus and Saccharomyces cerevisiae. Lambou K, et al. Yeast, 2010 Aug. PMID 20586114
    2. OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. Nakayama K, et al. EMBO J, 1992 Jul. PMID 1628616, Free PMC Article
    3. Glycoprotein biosynthesis in Saccharomyces cerevisiae: ngd29, an N-glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation. Lehle L, et al. FEBS Lett, 1995 Aug 14. PMID 7649302
    4. Glycoprotein biosynthesis in Saccharomyces cerevisiae. Partial purification of the alpha-1,6-mannosyltransferase that initiates outer chain synthesis. Romero PA, et al. Glycobiology, 1994 Apr. PMID 8054713
    5. Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae. Nakanishi-Shindo Y, et al. J Biol Chem, 1993 Dec 15. PMID 8253757

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolism of free oligosaccharides is facilitated in the och1Delta mutant of Saccharomyces cerevisiae.
      Title: Metabolism of free oligosaccharides is facilitated in the och1Δ mutant of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,6-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycolipid 1,6-alpha-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    initiation-specific alpha-1,6-mannosyltransferase
    NP_011477.1
    • Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      425362..426804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180903.1 → NP_011477.1  TPA: initiation-specific alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUA1, P31755
      UniProtKB/TrEMBL
      A6ZUV7, B3LIP9, B5VIS8, C7GT53, C8Z8K5, G2WE57, N1P1Y4
      Conserved Domains (1) summary
      COG3774
      Location:5 → 410
      OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31755.1

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