U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TYW3 tRNA methyltransferase TYW3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852832, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    TYW3
    Gene description
    tRNA methyltransferase TYW3
    Primary source
    FungiDB:YGL050W
    Locus tag
    YGL050W
    See related
    SGD:S000003018; AllianceGenome:SGD:S000003018; VEuPathDB:YGL050W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA methyltransferase activity. Involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TYW3 (tRNA-yW synthesizing protein 3 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TYW3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (405776..406597)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene DUP240 family protein MST27 Neighboring gene tRNA-Arg Neighboring gene translation initiation factor eIF4G Neighboring gene proteasome regulatory particle base subunit RPT6

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. Noma A, et al. EMBO J, 2006 May 17. PMID 16642040, Free PMC Article
    2. A novel assay provides insight into tRNAPhe retrograde nuclear import and re-export in S. cerevisiae. Nostramo RT, et al. Nucleic Acids Res, 2020 Nov 18. PMID 33074312, Free PMC Article
    3. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Noma A, et al. Nucleic Acids Symp Ser (Oxf), 2006. PMID 17150819
    4. Genome-wide analysis of the effects of heat shock on a Saccharomyces cerevisiae mutant with a constitutively activated cAMP-dependent pathway. Jones DL, et al. Comp Funct Genomics, 2004. PMID 18629174, Free PMC Article
    5. Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation. Chou HJ, et al. Mol Cell, 2017 Dec 7. PMID 29198561, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wybutosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tRNA methyltransferase TYW3
    NP_011465.3
    • tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      405776..406597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180915.3 → NP_011465.3  TPA: tRNA methyltransferase TYW3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011465.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU90, P53177
      UniProtKB/TrEMBL
      A0A6A5PVJ8, B3LIQ9, B5VIR9, C7GS27, C8Z8J4, G2WE46, N1P386
      Conserved Domains (1) summary
      pfam02676
      Location:10 → 227
      TYW3; Methyltransferase TYW3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53177.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools