U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SGF73 deubiquitination module subunit SGF73 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852814, updated on 28-Oct-2024

    Summary

    Official Symbol
    SGF73
    Official Full Name
    deubiquitination module subunit SGF73
    Primary source
    SGD:S000003034
    Locus tag
    YGL066W
    See related
    AllianceGenome:SGD:S000003034; FungiDB:YGL066W; VEuPathDB:YGL066W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCA7
    Summary
    Enables enzyme activator activity and structural molecule activity. Contributes to histone acetyltransferase activity. Involved in several processes, including mRNA export from nucleus; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and regulation of protein localization to chromatin. Located in cytosol and nucleus. Part of DUBm complex; SAGA complex; and SLIK (SAGA-like) complex. Used to study spinocerebellar ataxia type 7. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 7. Orthologous to human ATXN7L1 (ataxin 7 like 1). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SGF73 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (377609..379582)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MNP1 Neighboring gene NAD(+) diphosphatase Neighboring gene GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene ATP-dependent RNA helicase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural molecule activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DUBm complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SAGA complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of SLIK (SAGA-like) complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    deubiquitination module subunit SGF73
    NP_011449.1
    • Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      377609..379582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180931.1NP_011449.1  TPA: deubiquitination module subunit SGF73 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU75, P53165
      UniProtKB/TrEMBL
      A6ZUB0, B5VIQ7, N1P1W6
      Conserved Domains (2) summary
      pfam08313
      Location:219278
      SCA7; zinc-binding domain
      pfam18508
      Location:59100
      zf_C2H2_13; Zinc finger domain