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    ARO2 bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852729, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARO2
    Official Full Name
    bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
    Primary source
    SGD:S000003116
    Locus tag
    YGL148W
    See related
    AllianceGenome:SGD:S000003116; FungiDB:YGL148W; VEuPathDB:YGL148W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chorismate synthase activity and riboflavin reductase (NADPH) activity. Involved in aromatic amino acid family biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARO2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (226399..227529)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Nut1p Neighboring gene chromatin-remodeling ATPase INO80 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L9A Neighboring gene Rrt6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae. Quevillon-Cheruel S, et al. J Biol Chem, 2004 Jan 2. PMID 14573601
    2. Saccharomyces cerevisiae chorismate synthase has a flavin reductase activity. Henstrand JM, et al. Mol Microbiol, 1996 Dec. PMID 8971708
    3. Molecular cloning, characterization and analysis of the regulation of the ARO2 gene, encoding chorismate synthase, of Saccharomyces cerevisiae. Jones DG, et al. Mol Microbiol, 1991 Sep. PMID 1837329
    4. Effect of mutation in the aromatic amino acid pathway on sporulation of Saccharomyces cerevisiae. Lucchini G, et al. J Bacteriol, 1978 Oct. PMID 361708, Free PMC Article
    5. The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans. Chaillot J, et al. Antimicrob Agents Chemother, 2015 Aug. PMID 26014932, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chorismate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chorismate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chorismate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chorismate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorismate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
    NP_011367.1
    • Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      226399..227529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181013.1 → NP_011367.1  TPA: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU01, P28777
      UniProtKB/TrEMBL
      A6ZU35, B3LHK3, B5VII2, C7GPQ5, C8Z8A2, G2WDV5, N1P2X6
      Conserved Domains (1) summary
      TIGR00033
      Location:8 → 369
      aroC; chorismate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28777.1

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