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    GLO3 ADP-ribosylation factor GTPase-activating protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856859, updated on 6-Oct-2024

    Summary

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    Official Symbol
    GLO3
    Official Full Name
    ADP-ribosylation factor GTPase-activating protein
    Primary source
    SGD:S000000924
    Locus tag
    YER122C
    See related
    AllianceGenome:SGD:S000000924; FungiDB:YER122C; VEuPathDB:YER122C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in COPI coating of Golgi vesicle; endoplasmic reticulum to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in COPI-coated vesicle. Part of COPI vesicle coat. Orthologous to several human genes including ARFGAP2 (ADP ribosylation factor GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GLO3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (402871..404352, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-binding protein SCS2 Neighboring gene uncharacterized protein Neighboring gene casein kinase YCK3 Neighboring gene Dse1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ADP-ribosylation factor GTPase-activating protein Glo3p is involved in ER retrieval. Dogic D, et al. Eur J Cell Biol, 1999 May. PMID 10384981
    2. The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats. Xie B, et al. Adv Biol Regul, 2021 Jan. PMID 33436318, Free PMC Article
    3. Balanced trafficking between the ER and the Golgi apparatus increases protein secretion in yeast. Bao J, et al. AMB Express, 2018 Mar 12. PMID 29532188, Free PMC Article
    4. The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins. Kawada D, et al. Biochim Biophys Acta, 2015 Jan. PMID 25409928
    5. Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. DeRegis CJ, et al. BMC Cell Biol, 2008 Jan 22. PMID 18211691, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interaction between beta'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
      Title: An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
    2. The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
      Title: The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
    3. demonstrated that glo3Delta cells were defective in the late endosome-to-TGN transport pathway
      Title: The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins.
    4. The ArfGAP Gcs1p accelerates vesicle (v)-target membrane (t)-SNARE complex formation in vitro, indicating that ArfGAPs may act as folding chaperones.
      Title: Interaction of SNAREs with ArfGAPs precedes recruitment of Sec18p/NSF.
    5. The Glo3 and its homologues from other eukaryotes harbor a well-conserved repeated ISSxxxFG sequence near the C-terminus, which is not found in Gcs1p and its homologues.
      Title: The Arf1p GTPase-activating protein Glo3p executes its regulatory function through a conserved repeat motif at its C-terminus.
    6. role in the generation of COPI retrograde transport vesicles
      Title: The ArfGAP Glo3 is required for the generation of COPI vesicles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPI coating of Golgi vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in COPI coating of Golgi vesicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPI vesicle coat IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein
    NP_011048.1
    • ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      402871..404352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179012.1 → NP_011048.1  TPA: ADP-ribosylation factor GTPase-activating protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM28, P38682
      UniProtKB/TrEMBL
      B3LRN8
      Conserved Domains (1) summary
      COG5347
      Location:9 → 363
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38682.1

    Gene LinkOut

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