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    PTP3 tyrosine protein phosphatase PTP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856807, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PTP3
    Official Full Name
    tyrosine protein phosphatase PTP3
    Primary source
    SGD:S000000877
    Locus tag
    YER075C
    See related
    AllianceGenome:SGD:S000000877; FungiDB:YER075C; VEuPathDB:YER075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of cell wall integrity MAPK cascade; peptidyl-tyrosine dephosphorylation; and pheromone response MAPK cascade. Located in cytoplasm and nucleus. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PTP3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (308413..311199, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S24A Neighboring gene Yos1p Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A rate threshold mechanism regulates MAPK stress signaling and survival. Johnson AN, et al. Proc Natl Acad Sci U S A, 2021 Jan 12. PMID 33443180, Free PMC Article
    2. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Zhan XL, et al. Mol Biol Cell, 2000 Feb. PMID 10679022, Free PMC Article
    3. Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. Jacoby T, et al. J Biol Chem, 1997 Jul 11. PMID 9211927
    4. Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Mattison CP, et al. Genes Dev, 2000 May 15. PMID 10817757, Free PMC Article
    5. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Zhan XL, et al. Genes Dev, 1999 Nov 1. PMID 10557209, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A rate threshold mechanism regulates MAPK stress signaling and survival.
      Title: A rate threshold mechanism regulates MAPK stress signaling and survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic sequestering of protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization or biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell integrity MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sporulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine protein phosphatase PTP3
    NP_010998.2
    • Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      308413..311199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178966.2 → NP_010998.2  TPA: tyrosine protein phosphatase PTP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010998.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLY1, P40048
      UniProtKB/TrEMBL
      B3LRJ2, C7GRQ7, C8Z784
      Conserved Domains (2) summary
      cd01446
      Location:97 → 231
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd18533
      Location:571 → 873
      PTP_fungal; fungal protein tyrosine phosphatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40048.2

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