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    CIN10 Cin10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851995, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CIN10
    Gene description
    Cin10p
    Primary source
    FungiDB:YDR387C
    Locus tag
    YDR387C
    See related
    SGD:S000002795; AllianceGenome:SGD:S000002795; VEuPathDB:YDR387C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable myo-inositol:proton symporter activity. Predicted to be involved in transmembrane transport. Located in fungal-type vacuole membrane. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CIN10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1248154..1249821, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene elongation factor 2 Neighboring gene Mus81p Neighboring gene amphiphysin Neighboring gene GTPase-activating protein SAC7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. Palma M, et al. J Mol Microbiol Biotechnol, 2007. PMID 17587872
    2. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490
    3. The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation. Frumkin JP, et al. Nucleic Acids Res, 2016 Sep 30. PMID 27530428, Free PMC Article
    4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
    5. Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28. Zimmermann C, et al. G3 (Bethesda), 2017 Jun 7. PMID 28428242, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myo-inositol:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in myo-inositol import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myo-inositol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyol transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cin10p
    NP_010675.3
    • Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1248154..1249821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180695.3 → NP_010675.3  TPA: Cin10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010675.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT21, Q04162
      UniProtKB/TrEMBL
      A0A8H8UNT4, B3LFR3, C7GSD5, C8Z5V1, N1P741
      Conserved Domains (1) summary
      cd17360
      Location:45 → 528
      MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04162.1

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