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    FRQ1 frequenin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851979, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FRQ1
    Official Full Name
    frequenin
    Primary source
    SGD:S000002781
    Locus tag
    YDR373W
    See related
    AllianceGenome:SGD:S000002781; FungiDB:YDR373W; VEuPathDB:YDR373W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme activator activity. Involved in regulation of signal transduction. Located in Golgi membrane. Orthologous to several human genes including NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FRQ1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1222759..1223331)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative chitinase Neighboring gene Vps74p Neighboring gene mRNA-binding phosphate metabolism regulator Neighboring gene Wip1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae. Ames JB, et al. Biochemistry, 2000 Oct 10. PMID 11015193
    2. Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1. Huttner IG, et al. J Biol Chem, 2003 Feb 14. PMID 12477731
    3. Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers calcium tolerance. Hamasaki-Katagiri N, et al. J Biol Chem, 2004 Mar 26. PMID 14722091
    4. Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase. Hendricks KB, et al. Nat Cell Biol, 1999 Aug. PMID 10559922
    5. Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1). Strahl T, et al. J Biol Chem, 2007 Oct 19. PMID 17720810

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    frequenin
    NP_010661.3
    • N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1222759..1223331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180681.3 → NP_010661.3  TPA: frequenin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010661.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT04, Q06389
      UniProtKB/TrEMBL
      A6ZYX1, B3LFT0, B5VGQ3, C7GMG4, C8Z5T5, G2WBA9, N1P7A6
      Conserved Domains (1) summary
      COG5126
      Location:4 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06389.2

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