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    TPPP tubulin polymerization promoting protein [ Homo sapiens (human) ]

    Gene ID: 11076, updated on 14-Nov-2024

    Summary

    Official Symbol
    TPPPprovided by HGNC
    Official Full Name
    tubulin polymerization promoting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:24164
    See related
    Ensembl:ENSG00000171368 MIM:608773; AllianceGenome:HGNC:24164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p24; p25; TPPP1; TPPP/p25; p25alpha
    Summary
    Enables several functions, including magnesium ion binding activity; microtubule nucleator activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including cytoskeleton; mitochondrion; and perinuclear region of cytoplasm. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TPPP in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (659862..700727, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (657955..690778, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (659977..693467, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:570939-571526 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86692/86693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86701 Neighboring gene uncharacterized LOC105374608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:602876-603376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:603377-603877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:611378-612308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:612309-613238 Neighboring gene CEP72 divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:618691-619890 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86736 Neighboring gene centrosomal protein 72 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643172-643672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643673-644173 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86745 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86749/86750 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86753 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:669166-669920 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86803 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:673521-674090 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86819 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_86823 and experimental_86827 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86831 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86835 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86841/86842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:686929-687430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:692893-693475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15876 Neighboring gene uncharacterized LOC101929898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:694389-695267 Neighboring gene NANOG hESC enhancer GRCh37_chr5:708729-709282 Neighboring gene zinc finger DHHC-type containing 11B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:727349-727849 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:752062-752252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:753615-754114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:758511-759354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:759355-760198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:771879-772522 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:782879-783538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:785123-785861 Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:794321-795181 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:811555-811724 Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene signal peptidase complex subunit 2 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tubulin polymerization promoting protein (TPPP) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activity PubMed 
    enables magnesium ion binding PubMed 
    enables membrane scission GTPase motor activity  
    enables microtubule binding  
    enables microtubule nucleator activity PubMed 
    enables protein binding PubMed 
    enables protein dimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables tubulin binding  
    enables tubulin binding PubMed 
    enables tubulin binding  
    Process Evidence Code Pubs
    involved_in astral microtubule organization PubMed 
    involved_in cell division  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation PubMed 
    involved_in microtubule bundle formation  
    involved_in microtubule nucleation by microtubule organizing center PubMed 
    involved_in microtubule polymerization  
    involved_in microtubule polymerization PubMed 
    involved_in microtubule polymerization  
    involved_in myelin assembly  
    involved_in negative regulation of tubulin deacetylation PubMed 
    involved_in oligodendrocyte development  
    involved_in oligodendrocyte differentiation  
    involved_in positive regulation of myelination  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of protein polymerization PubMed 
    involved_in positive regulation of protein-containing complex assembly  
    involved_in regulation of microtubule cytoskeleton organization PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol  
    colocalizes_with microtubule  
    colocalizes_with microtubule PubMed 
    colocalizes_with microtubule bundle PubMed 
    located_in microtubule organizing center  
    located_in mitochondrion  
    located_in mitotic spindle PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    located_in postsynaptic Golgi apparatus  

    General protein information

    Preferred Names
    tubulin polymerization-promoting protein
    Names
    25 kDa brain-specific protein
    brain specific protein p25 alpha
    glycogen synthase kinase 3 (GSK3) inhibitor p24
    p25-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007030.3NP_008961.1  tubulin polymerization-promoting protein

      See identical proteins and their annotated locations for NP_008961.1

      Status: VALIDATED

      Source sequence(s)
      AB017016, AI796918, AW955330, BQ066916, BU726600, DB478250, DB546894
      Consensus CDS
      CCDS3856.1
      UniProtKB/Swiss-Prot
      O94811
      UniProtKB/TrEMBL
      Q4L233
      Related
      ENSP00000353785.5, ENST00000360578.7
      Conserved Domains (1) summary
      pfam05517
      Location:52207
      p25-alpha; p25-alpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      659862..700727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024454346.1XP_024310114.1  tubulin polymerization-promoting protein isoform X2

      UniProtKB/Swiss-Prot
      O94811
      UniProtKB/TrEMBL
      Q4L233
      Conserved Domains (1) summary
      pfam05517
      Location:52207
      p25-alpha; p25-alpha
    2. XM_047416674.1XP_047272630.1  tubulin polymerization-promoting protein isoform X2

      UniProtKB/Swiss-Prot
      O94811
      UniProtKB/TrEMBL
      Q4L233
    3. XM_017008993.2XP_016864482.1  tubulin polymerization-promoting protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      657955..690778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351515.1XP_054207490.1  tubulin polymerization-promoting protein isoform X3

    2. XM_054351516.1XP_054207491.1  tubulin polymerization-promoting protein isoform X2

      UniProtKB/Swiss-Prot
      O94811
      UniProtKB/TrEMBL
      Q4L233
    3. XM_054351514.1XP_054207489.1  tubulin polymerization-promoting protein isoform X3

    4. XM_054351513.1XP_054207488.1  tubulin polymerization-promoting protein isoform X3

    5. XM_054351512.1XP_054207487.1  tubulin polymerization-promoting protein isoform X1

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