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    YCX1 Ycx1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851321, updated on 2-Nov-2024

    Summary

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    Official Symbol
    YCX1
    Official Full Name
    Ycx1p
    Primary source
    SGD:S000002365
    Locus tag
    YDL206W
    See related
    AllianceGenome:SGD:S000002365; FungiDB:YDL206W; VEuPathDB:YDL206W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable monoatomic cation transmembrane transporter activity. Acts upstream of or within calcineurin-mediated signaling. Located in fungal-type vacuole membrane. Is active in Golgi apparatus and endoplasmic reticulum. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See YCX1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (90176..92464)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene snoRNA-binding protein NHP2 Neighboring gene nucleoporin GLE1 Neighboring gene hydroxymethylbilane synthase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ycx1 protein encoded by the yeast YDL206W gene plays a role in calcium and calcineurin signaling. Lee GM, et al. J Biol Chem, 2023 May. PMID 36965615, Free PMC Article
    2. An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae. Lesage G, et al. BMC Genet, 2005 Feb 16. PMID 15715908, Free PMC Article
    3. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
    4. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. Colomina N, et al. J Biol Chem, 2008 Oct 17. PMID 18667435, Free PMC Article
    5. Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Voynova NS, et al. Eukaryot Cell, 2015 Dec. PMID 26432633, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ycx1 protein encoded by the yeast YDL206W gene plays a role in calcium and calcineurin signaling.
      Title: The Ycx1 protein encoded by the yeast YDL206W gene plays a role in calcium and calcineurin signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcineurin-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ycx1p
    NP_010075.1
    • Protein involved in calcium-induced activation of calcineurin; homologous to proteins in Candida and Cryptococcus; YCX1 is not an essential protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      90176..92464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180266.1 → NP_010075.1  TPA: Ycx1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRE8, Q12424
      UniProtKB/TrEMBL
      G2WBW1, N1P6F7
      Conserved Domains (1) summary
      COG0530
      Location:28 → 223
      ECM27; Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12424.1

    Gene LinkOut

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