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    ACK1 Ack1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851324, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ACK1
    Official Full Name
    Ack1p
    Primary source
    SGD:S000002362
    Locus tag
    YDL203C
    See related
    AllianceGenome:SGD:S000002362; FungiDB:YDL203C; VEuPathDB:YDL203C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in fungal-type cell wall organization and positive regulation of signal transduction. Located in mitochondrion. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ACK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (96082..97953, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rtn2p Neighboring gene mitochondrial 54S ribosomal protein YmL11 Neighboring gene tRNA (guanine46-N7)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The functional relationships underlying a synthetic genetic network. Krause SA, et al. Commun Integr Biol, 2009. PMID 19704853, Free PMC Article
    2. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. Kus B, et al. J Biol Chem, 2005 Aug 19. PMID 15955809
    3. The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose. Defenouillère Q, et al. Sci Signal, 2019 Sep 3. PMID 31481524
    4. Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Piotrowski JS, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775513, Free PMC Article
    5. The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Krause SA, et al. Eukaryot Cell, 2008 Nov. PMID 18806213, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Ack1p
    NP_010078.1
    • Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      96082..97953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180263.1 → NP_010078.1  TPA: Ack1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRF1, Q07622
      UniProtKB/TrEMBL
      G2WBW4, N1P8D5
      Conserved Domains (3) summary
      smart00671
      Location:318 → 361
      SEL1; Sel1-like repeats
      COG0790
      Location:342 → 623
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:345 → 374
      SLR; SLR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07622.1

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