RSA4 Rsa4p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RSA4
Official Full Name: Rsa4p
Primary source: SGD:S000000668
Locus tag: YCR072C
See related: AllianceGenome:SGD:S000000668; FungiDB:YCR072C; VEuPathDB:YCR072C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in protein-RNA complex remodeling and ribosomal large subunit assembly. Located in nucleolus. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RSA4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (240805..242352, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rsa4p provides a platform of interaction for correct processing of rRNA precursors and nucleolar release of 60S ribosomal subunits.
Title: The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in protein-RNA complex remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rsa4p

NP_009997.2

Ribosomal large subunit (60S) assembly factor; association of the N-terminal ubiquitin-like (UBL) domain of this preribosomal factor with the MIDAS domain in the Rea1p tail, promoted by the GTPase Nog2p, is required for the ATP-dependent dissociation of preribosomal factors including the Rix1p subcomplex, Rea1p, Nog2p and Rsa1p itself prior to nuclear export of pre-60S particles; contains WD-repeats and a UBL domain; localizes to the nucleolus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

240805..242352 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178782.1 → NP_009997.2 TPA: Rsa4p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009997.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR74, P25382, Q8NKJ4

UniProtKB/TrEMBL

A6ZTP5, B3LUC9, B5VF03, C7GUX4, C8Z4F9, G2WA81, N1P7P7

Conserved Domains (4) summary

smart00320
Location:475 → 513

WD40; WD40 repeats

cd00200
Location:135 → 472

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:189 → 227

7WD40; WD40 repeat [structural motif]

pfam08154
Location:32 → 79

NLE; NLE (NUC135) domain