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    RBP95 RNA-binding ribosome assembly factor RBP95 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850375, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RBP95
    Official Full Name
    RNA-binding ribosome assembly factor RBP95
    Primary source
    SGD:S000000609
    Locus tag
    YCR016W
    See related
    AllianceGenome:SGD:S000000609; FungiDB:YCR016W; VEuPathDB:YCR016W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in maturation of LSU-rRNA. Located in nucleus. Is active in nucleolus. Orthologous to human C7orf50 (chromosome 7 open reading frame 50). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See RBP95 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (143634..144506)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene Cwh43p Neighboring gene Srd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory. Luo F, et al. BMC Bioinformatics, 2007 Aug 14. PMID 17697349, Free PMC Article
    2. Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses. Ouyang X, et al. Free Radic Biol Med, 2011 Jan 1. PMID 20971184
    3. Loss of Dfg5 glycosylphosphatidylinositol-anchored membrane protein confers enhanced heat tolerance in Saccharomyces cerevisiae. Nasution O, et al. Environ Microbiol, 2015 Aug. PMID 25297926
    4. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271
    5. Genome-wide identification of genes that play a role in boron stress response in yeast. Uluisik I, et al. Genomics, 2011 Feb. PMID 21035538

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation.
      Title: Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    RNA-binding ribosome assembly factor RBP95
    NP_009942.2
    • RNA-binding ribosome assembly factor; constituent of early pre-60S particles; genetically and physically linked to most NOP8 60s ribosome pre-assembly complex members and to ribosomal protein Rpl3p; contains two independent RNA-interacting domains; associates with helix H95 in 3' region of 25S rRNA, in close proximity to binding sites of Npa1p and Rpl3p; interacts with several snoRNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      143634..144506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178729.1 → NP_009942.2  TPA: RNA-binding ribosome assembly factor RBP95 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009942.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR24, P25617, Q8NIM2
      UniProtKB/TrEMBL
      B3LU88, B5VEW3, C7GT45, C8Z4A3, G2WA32, N1P7U1
      Conserved Domains (1) summary
      pfam10180
      Location:148 → 196
      DUF2373; Uncharacterized conserved protein (DUF2373)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25617.2

    Gene LinkOut

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