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    ATG14 Atg14p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852425, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ATG14
    Gene description
    Atg14p
    Primary source
    FungiDB:YBR128C
    Locus tag
    YBR128C
    See related
    SGD:S000000332; AllianceGenome:SGD:S000000332; VEuPathDB:YBR128C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APG14; CVT12
    Summary
    Involved in several processes, including autophagy of peroxisome; cytoplasm to vacuole transport by the Cvt pathway; and piecemeal microautophagy of the nucleus. Located in fungal-type vacuole membrane; phagophore assembly site; and vacuole-isolation membrane contact site. Is extrinsic component of membrane. Part of phosphatidylinositol 3-kinase complex, class III, type I. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATG14 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (493081..494115, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Meo1p Neighboring gene H(+)-transporting V1 sector ATPase subunit B Neighboring gene Opy1p Neighboring gene She3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy-related protein MoAtg14 is involved in differentiation, development and pathogenicity in the rice blast fungus Magnaporthe oryzae. Liu XH, et al. Sci Rep, 2017 Jan 9. PMID 28067330, Free PMC Article
    2. Autophagy regulator Atg9 is degraded by the proteasome. Hu G, et al. Biochem Biophys Res Commun, 2020 Jan 29. PMID 31759633, Free PMC Article
    3. What the N-terminal domain of Atg13 looks like and what it does: a HORMA fold required for PtdIns 3-kinase recruitment. Jao CC, et al. Autophagy, 2013 Jul. PMID 23670046, Free PMC Article
    4. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. Kametaka S, et al. J Biol Chem, 1998 Aug 28. PMID 9712845
    5. A nuclear membrane-derived structure associated with Atg8 is involved in the sequestration of selective cargo, the Cvt complex, during autophagosome formation in yeast. Baba M, et al. Autophagy, 2019 Mar. PMID 30238844, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (micro-lipophagy), in which fat is metabolized as an alternative energy source. AMP-activated protein kinase (AMPK) activation triggered this pathway, which required Atg14p.
      Title: AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation.
    2. Deletion analysis of Atg14p revealed that N-terminal region containing the coiled-coil structures was essential and sufficient for autophagy.
      Title: Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to potassium ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole-isolation membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Atg14p
    NP_009686.1
    • Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      493081..494115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178476.1 → NP_009686.1  TPA: Atg14p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQC5, P38270
      UniProtKB/TrEMBL
      A0A8H4F6L8, B3LN28, B5VE88, C7GY11, N1P879
      Conserved Domains (1) summary
      pfam10186
      Location:3 → 224
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38270.1

    Gene LinkOut

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