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    LYS2 L-aminoadipate-semialdehyde dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852412, updated on 29-Jun-2024

    Summary

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    Gene symbol
    LYS2
    Gene description
    L-aminoadipate-semialdehyde dehydrogenase
    Primary source
    FungiDB:YBR115C
    Locus tag
    YBR115C
    See related
    SGD:S000000319; AllianceGenome:SGD:S000000319; VEuPathDB:YBR115C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-aminoadipate-semialdehyde dehydrogenase activity. Involved in lysine biosynthetic process via aminoadipic acid. Orthologous to human AASDH (aminoadipate-semialdehyde dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LYS2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (469748..473926, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene transcription regulator CYC8 Neighboring gene DNA repair protein RAD16 Neighboring gene transketolase TKL2 Neighboring gene translation elongation factor EF-1 alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing and characterization of the alpha-aminoadipate reductase gene (LYS2) from Saccharomycopsis fibuligera. Yan H, et al. Yeast, 2007 Mar. PMID 17351909
    2. [Frameshift suppression through inactivation of translation termination in yeast Saccharomyces cerevisiae: significance of the local context]. Riabnikova NA, et al. Genetika, 2004 Jul. PMID 15458198
    3. Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast. Lippert MJ, et al. Mol Cell Biol, 2004 Jun. PMID 15143174, Free PMC Article
    4. Identification of the cloned S. cerevisiae LYS2 gene by an integrative transformation approach. Eibel H, et al. Mol Gen Genet, 1983. PMID 6350829
    5. Lysine biosynthesis in Saccharomyces. Conversion of -aminoadipate into -aminoadipic -semialdehyde. Sinha AK, et al. Biochem J, 1971 Dec. PMID 4401608, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lys2 interaction with FLO8, STE11, SPT6 and RNA Polymerase II
      Title: Relationships Between RNA Polymerase II Activity and Spt Elongation Factors to Spt- Phenotype and Growth in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-aminoadipate-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-aminoadipate-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-aminoadipate-semialdehyde dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via aminoadipic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-aminoadipate-semialdehyde dehydrogenase
    NP_009673.1
    • Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      469748..473926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178463.1 → NP_009673.1  TPA: L-aminoadipate-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQB4, P07702
      UniProtKB/TrEMBL
      A0A8H4F7X1, B5VE77, N1P6N2
      Conserved Domains (1) summary
      TIGR03443
      Location:7 → 1379
      alpha_am_amid; L-aminoadipate-semialdehyde dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07702.2

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