POL30 proliferating cell nuclear antigen [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: POL30
Gene description: proliferating cell nuclear antigen
Primary source: FungiDB:YBR088C
Locus tag: YBR088C
See related: SGD:S000000292; AllianceGenome:SGD:S000000292; VEuPathDB:YBR088C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA polymerase processivity factor activity. Involved in DNA metabolic process; chromosome organization; and positive regulation of hydrolase activity. Located in nucleus and replication fork. Part of PCNA complex. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See POL30 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (424990..425766, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the PCNA unloader Elg1-RFC.
Title: Structure of the PCNA unloader Elg1-RFC.
Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.
Title: Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.
PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation.
Title: PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation.
Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Poleta/PCNA complex.
Title: Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Polη/PCNA complex.
Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair.
Title: Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair.
Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.
Title: Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.
DNA-damage tolerance through PCNA ubiquitination and sumoylation.
Title: DNA-damage tolerance through PCNA ubiquitination and sumoylation.
the silencing-loss phenotypes of pol30-6 and pol30-79 depended on ploidy, but not on POL30 dosage or mating-type identity. Separately from silencing loss, the pol30-6 and pol30-79 alleles also displayed high levels of mitotic recombination in diploids. These results established that histone trafficking involving PCNA at replication forks is crucial to the maintenance of chromatin state and genome stability during DNA repl
Title: Mutations in the PCNA DNA Polymerase Clamp of Saccharomyces cerevisiae Reveal Complexities of the Cell Cycle and Ploidy on Heterochromatin Assembly.
PCNA retention controlled by the Elg1 complex is critical for efficient MMR: PCNA needs to be on DNA long enough to enable MMR, but if it is retained too long it interferes with downstream repair steps.
Title: Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
proliferating cell nuclear antigen (PCNA) unloading activity of Elg1 is important for coordinating DNA replication forks with the process of replication-coupled nucleosome assembly to maintain silencing of HML and HMR through S-phase
Title: Pivotal roles of PCNA loading and unloading in heterochromatin function.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase processivity factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in error-free translesion synthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lagging strand elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in lagging strand elongation	IPI Inferred from Physical Interaction more info	PubMed
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of DNA trinucleotide repeats	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of DNA trinucleotide repeats	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic mismatch repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic mismatch repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mismatch repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid cohesion	IPI Inferred from Physical Interaction more info	PubMed
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in postreplication repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postreplication repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in silent mating-type cassette heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PCNA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PCNA complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in replication fork	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proliferating cell nuclear antigen

NP_009645.1

Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays crucial role during Okazaki fragment processing; Leu164 is essential for stable complex formation with replicative DNA polymerase delta