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    SEC8 exocyst subunit SEC8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856168, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SEC8
    Official Full Name
    exocyst subunit SEC8
    Primary source
    SGD:S000006259
    Locus tag
    YPR055W
    See related
    AllianceGenome:SGD:S000006259; FungiDB:YPR055W; VEuPathDB:YPR055W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in Golgi to plasma membrane transport; exocytosis; and organelle inheritance. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of exocyst. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SEC8 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (667676..670873)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene mitogen-activated protein kinase SMK1 Neighboring gene TFIIH/NER complex subunit TFB4 Neighboring gene Brr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Golgi inheritance in small buds of Saccharomyces cerevisiae is linked to endoplasmic reticulum inheritance. Reinke CA, et al. Proc Natl Acad Sci U S A, 2004 Dec 28. PMID 15596717, Free PMC Article
    2. SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Potenza M, et al. Yeast, 1992 Jul. PMID 1523887
    3. Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum. Wiederkehr A, et al. Mol Biol Cell, 2003 Dec. PMID 12960429, Free PMC Article
    4. Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particle. Bowser R, et al. J Cell Biol, 1991 Mar. PMID 1900300, Free PMC Article
    5. Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis. Bowser R, et al. J Cell Biol, 1992 Sep. PMID 1512289, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    exocyst subunit SEC8
    NP_015380.1
    • Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      667676..670873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184152.1 → NP_015380.1  TPA: exocyst subunit SEC8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W461, P32855
      UniProtKB/TrEMBL
      B3LLB0, C7GY42, C8ZJ80, G2WPM9, N1NW19
      Conserved Domains (1) summary
      pfam04048
      Location:34 → 174
      Sec8_exocyst; Sec8 exocyst complex component specific domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32855.1

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