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    TFB4 TFIIH/NER complex subunit TFB4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856169, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TFB4
    Gene description
    TFIIH/NER complex subunit TFB4
    Primary source
    FungiDB:YPR056W
    Locus tag
    YPR056W
    See related
    SGD:S000006260; AllianceGenome:SGD:S000006260; VEuPathDB:YPR056W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TFB4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (671126..672142)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase SMK1 Neighboring gene exocyst subunit SEC8 Neighboring gene Brr1p Neighboring gene organic acid transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TFB4 subunit of yeast TFIIH is required for both nucleotide excision repair and RNA polymerase II transcription. Feaver WJ, et al. J Biol Chem, 1999 Oct 8. PMID 10506223
    2. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Takagi Y, et al. Mol Cell, 2005 Apr 15. PMID 15837426
    3. Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. Feaver WJ, et al. J Biol Chem, 1997 Aug 1. PMID 9235928
    4. Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Keogh MC, et al. Mol Cell Biol, 2002 Mar. PMID 11839796, Free PMC Article
    5. Transcription of eukaryotic protein-coding genes. Lee TI, et al. Annu Rev Genet, 2000. PMID 11092823

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TFIIH/NER complex subunit TFB4
    NP_015381.1
    • Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      671126..672142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184153.1 → NP_015381.1  TPA: TFIIH/NER complex subunit TFB4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015381.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W462, Q12004
      UniProtKB/TrEMBL
      A0A8H4BW51, A6ZWU5, B3LLB1, C7GY43, C8ZJ81, G2WPN0, N1P251
      Conserved Domains (1) summary
      COG5242
      Location:1 → 331
      TFB4; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 [Transcription / DNA replication, recombination, and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12004.1

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