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    YMC1 organic acid transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856171, updated on 2-Nov-2024

    Summary

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    Official Symbol
    YMC1
    Official Full Name
    organic acid transporter
    Primary source
    SGD:S000006262
    Locus tag
    YPR058W
    See related
    AllianceGenome:SGD:S000006262; FungiDB:YPR058W; VEuPathDB:YPR058W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycine transmembrane transporter activity. Involved in glycine import into mitochondrion and heme biosynthetic process. Located in mitochondrion. Orthologous to several human genes including SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See YMC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (673751..674674)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene TFIIH/NER complex subunit TFB4 Neighboring gene Brr1p Neighboring gene chorismate mutase ARO7 Neighboring gene Jid1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YMC1, a yeast gene encoding a new putative mitochondrial carrier protein. Graf R, et al. Yeast, 1993 Mar. PMID 8488731
    2. Mitochondrial transporters involved in oleic acid utilization and glutamate metabolism in yeast. Trotter PJ, et al. Arch Biochem Biophys, 2005 Oct 1. PMID 16140254
    3. Sym1, the yeast ortholog of the MPV17 human disease protein, is a stress-induced bioenergetic and morphogenetic mitochondrial modulator. Dallabona C, et al. Hum Mol Genet, 2010 Mar 15. PMID 20042463
    4. The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins. Laborenz J, et al. Mol Biol Cell, 2021 Apr 15. PMID 33596095, Free PMC Article
    5. Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. el Moualij B, et al. Yeast, 1997 May. PMID 9178508

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables organic acid transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables organic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycine import into mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    organic acid transporter
    NP_015383.1
    • Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      673751..674674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184155.1 → NP_015383.1  TPA: organic acid transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W464, P32331, Q12002
      UniProtKB/TrEMBL
      A6ZWU7, B3LLB3, C7GY45, C8ZJ83, G2WPN2, N1NXK4
      Conserved Domains (1) summary
      pfam00153
      Location:215 → 307
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32331.2

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