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    SMK1 mitogen-activated protein kinase SMK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856167, updated on 2-Nov-2024

    Summary

    Official Symbol
    SMK1
    Official Full Name
    mitogen-activated protein kinase SMK1
    Primary source
    SGD:S000006258
    Locus tag
    YPR054W
    See related
    AllianceGenome:SGD:S000006258; FungiDB:YPR054W; VEuPathDB:YPR054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables MAP kinase activity. Acts upstream of or within ascospore wall assembly and protein localization to ascospore wall. Located in prospore membrane leading edge. Orthologous to human MAPK7 (mitogen-activated protein kinase 7) and NLK (nemo like kinase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See SMK1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (666280..667446)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene peptide alpha-N-acetyltransferase MAK3 Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene exocyst subunit SEC8 Neighboring gene TFIIH/NER complex subunit TFB4

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein localization to ascospore wall IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in prospore membrane leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase SMK1
    NP_015379.1
    • Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      666280..667446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184151.1NP_015379.1  TPA: mitogen-activated protein kinase SMK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015379.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W460, P41808
      UniProtKB/TrEMBL
      B3LLA9, C7GY41, C8ZJ79, G2WPM8, N1NXK0
      Conserved Domains (1) summary
      cl21453
      Location:37376
      PKc_like; Protein Kinases, catalytic domain