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    MSY1 tyrosine--tRNA ligase MSY1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856007, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSY1
    Official Full Name
    tyrosine--tRNA ligase MSY1
    Primary source
    SGD:S000006018
    Locus tag
    YPL097W
    See related
    AllianceGenome:SGD:S000006018; FungiDB:YPL097W; VEuPathDB:YPL097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tyrosine-tRNA ligase activity. Involved in mitochondrial tyrosyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MSY1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (364952..366430)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ina17p Neighboring gene Mgr2p Neighboring gene Eri1p Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo. Edwards H, et al. Cell, 1987 Nov 20. PMID 3315228
    2. The yeast model suggests the use of short peptides derived from mt LeuRS for the therapy of diseases due to mutations in several mt tRNAs. Di Micco P, et al. Biochim Biophys Acta, 2014 Dec. PMID 25261707
    3. RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae. Imamura Y, et al. PLoS One, 2015. PMID 26086550, Free PMC Article
    4. The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Kochan DZ, et al. J Cell Sci, 2021 Aug 1. PMID 34350963, Free PMC Article
    5. A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Wilfling F, et al. Mol Cell, 2020 Dec 3. PMID 33207182, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial tyrosyl-tRNA aminoacylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine--tRNA ligase MSY1
    NP_015228.1
    • Mitochondrial tyrosyl-tRNA synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      364952..366430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183911.1 → NP_015228.1  TPA: tyrosine--tRNA ligase MSY1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3R9, P48527
      UniProtKB/TrEMBL
      A6ZWF3, B3LKX5, B5VT64, N1NW33
      Conserved Domains (1) summary
      TIGR00234
      Location:54 → 471
      tyrS; tyrosyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48527.1

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