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    SET6 Set6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855938, updated on 17-May-2024

    Summary

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    Gene symbol
    SET6
    Gene description
    Set6p
    Primary source
    FungiDB:YPL165C
    Locus tag
    YPL165C
    See related
    SGD:S000006086; AllianceGenome:SGD:S000006086; VEuPathDB:YPL165C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable histone-lysine N-methyltransferase activity. Predicted to be involved in histone lysine methylation. Predicted to be active in nucleus. Orthologous to several human genes including SMYD2 (SET and MYND domain containing 2) and SMYD3 (SET and MYND domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SET6 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (237956..239077, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrx4p Neighboring gene DNA-directed DNA polymerase Neighboring gene Atg29p Neighboring gene mismatch repair protein MLH3 Neighboring gene Svs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Giaever G, et al. Proc Natl Acad Sci U S A, 2004 Jan 20. PMID 14718668, Free PMC Article
    2. FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. Helliwell SB, et al. Nat Commun, 2015 Oct 12. PMID 26456460, Free PMC Article
    3. Evolution of SET-domain protein families in the unicellular and multicellular Ascomycota fungi. Veerappan CS, et al. BMC Evol Biol, 2008 Jul 1. PMID 18593478, Free PMC Article
    4. The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Tripic T, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16329992
    5. Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Schibler A, et al. Genes Dev, 2016 May 15. PMID 27198228, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Set6p
    NP_015160.1
    • SET domain hypothetical protein; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      237956..239077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183979.1 → NP_015160.1  TPA: Set6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3K3, Q12529
      UniProtKB/TrEMBL
      A0A8H4BVY8, B5VT05, C7GJB7
      Conserved Domains (1) summary
      COG2940
      Location:1 → 370
      SET; SET domain-containing protein (function unknown) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12529.1

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