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    CDC60 leucine--tRNA ligase CDC60 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855943, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CDC60
    Official Full Name
    leucine--tRNA ligase CDC60
    Primary source
    SGD:S000006081
    Locus tag
    YPL160W
    See related
    AllianceGenome:SGD:S000006081; FungiDB:YPL160W; VEuPathDB:YPL160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables leucine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in leucyl-tRNA aminoacylation and regulation of TORC1 signaling. Located in cytoplasm. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CDC60 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (246990..250262)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bem4p Neighboring gene Pet20p Neighboring gene Aim44p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic studies of leucyl transfer RNA synthetase from bakers' yeast. Order of addition of substrates and release of products. Lin CS, et al. J Biol Chem, 1975 Dec 25. PMID 172506
    2. The cell division cycle gene CDC60 encodes cytosolic leucyl-tRNA synthetase in Saccharomyces cerevisiae. Hohmann S, et al. Gene, 1992 Oct 12. PMID 1398122
    3. Amino-acid-dependent shift in tRNA synthetase editing mechanisms. Sarkar J, et al. J Am Chem Soc, 2011 Nov 23. PMID 22017352, Free PMC Article
    4. Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap. Sarkar J, et al. FEBS Lett, 2011 Oct 3. PMID 21856301, Free PMC Article
    5. Crystallization of tRNA Leu -synthetase from baker's yeast. Chirikjian JG, et al. Proc Natl Acad Sci U S A, 1972 Jun. PMID 4504381, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables leucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of TORC1 signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine--tRNA ligase CDC60
    NP_015165.1
    • Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      246990..250262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183974.1 → NP_015165.1  TPA: leucine--tRNA ligase CDC60 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3K8, P26637
      UniProtKB/TrEMBL
      A6ZW93, B3LKR7, C7GJB2, N1NW09
      Conserved Domains (1) summary
      TIGR00395
      Location:17 → 1088
      leuS_arch; leucyl-tRNA synthetase, archaeal and cytosolic family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26637.1

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