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    TGS1 RNA methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855946, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TGS1
    Official Full Name
    RNA methyltransferase
    Primary source
    SGD:S000006078
    Locus tag
    YPL157W
    See related
    AllianceGenome:SGD:S000006078; FungiDB:YPL157W; VEuPathDB:YPL157W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA methyltransferase activity. Involved in several processes, including RNA processing; nucleologenesis; and regulation of telomere maintenance via telomerase. Located in nucleolus. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TGS1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (254814..255761)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pet20p Neighboring gene Aim44p Neighboring gene pheromone-regulated protein PRM4 Neighboring gene Kip2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase. Mouaikel J, et al. Nucleic Acids Res, 2003 Aug 15. PMID 12907733, Free PMC Article
    2. The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology. Colau G, et al. Mol Cell Biol, 2004 Sep. PMID 15340060, Free PMC Article
    3. Characterization of a mimivirus RNA cap guanine-N2 methyltransferase. Benarroch D, et al. RNA, 2009 Apr. PMID 19218551, Free PMC Article
    4. Trimethylguanosine Synthase1 (TGS1) Is Essential for Chilling Tolerance. Gao J, et al. Plant Physiol, 2017 Jul. PMID 28495891, Free PMC Article
    5. Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. Boon KL, et al. Sci Rep, 2015 Jun 15. PMID 26074133, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Self-association of Tgs1p and its catalytic activity were prerequisite to bypass the requirement for its accessory factor Swm2p for efficient pre-rRNA processing and snRNA trimethylation.
      Title: Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing.
    2. exploited the synthetic lethal interactions of tgs1Delta and mud2Delta mutations to identify essential structural features of the Tgs1 and Mud2 proteins
      Title: Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing.
    3. methyltransferase Tgs1 has a role in the coordination between telomerase and DNA polymerase for end replication
      Title: Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1.
    4. present a biochemical characterization of the human Tgs1 guanine-N2 methyltransferase reaction and identify individual amino acids required for methyltransferase activity in vitro and in vivo
      Title: Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA cap trimethylguanosine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine cap hypermethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine cap hypermethylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 7-methylguanosine cap hypermethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleologenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA methyltransferase
    NP_015168.1
    • Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      254814..255761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183971.1 → NP_015168.1  TPA: RNA methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3L1, Q12052
      UniProtKB/TrEMBL
      A6ZW96, C8ZIM1, N1NVF8
      Conserved Domains (1) summary
      pfam09445
      Location:98 → 262
      Methyltransf_15; RNA cap guanine-N2 methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12052.1

    Gene LinkOut

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