POS5 NADH kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: POS5
Official Full Name: NADH kinase
Primary source: SGD:S000006109
Locus tag: YPL188W
See related: AllianceGenome:SGD:S000006109; FungiDB:YPL188W; VEuPathDB:YPL188W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NADH kinase activity. Involved in NADP biosynthetic process; cellular response to oxidative stress; and iron-sulfur cluster assembly. Located in mitochondrion. Is active in mitochondrial matrix. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See POS5 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (191406..192650)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Redox Engineering by Ectopic Overexpression of NADH Kinase in Recombinant Pichia pastoris (Komagataella phaffii): Impact on Cell Physiology and Recombinant Production of Secreted Proteins.
Title: Redox Engineering by Ectopic Overexpression of NADH Kinase in Recombinant Pichia pastoris (Komagataella phaffii): Impact on Cell Physiology and Recombinant Production of Secreted Proteins.
the specific function of Pos5p in mitochondrial NADP(+) and NADPH biosynthesis.
Title: Effects of a mitochondrial mutator mutation in yeast POS5 NADH kinase on mitochondrial nucleotides.
Arg-293 of Pos5 is a major determinant of NADH selectivity. Moreover, Ser-272 appears to assist Arg-293 in achieving the appropriate conformation.
Title: Structural determinants of discrimination of NAD+ from NADH in yeast mitochondrial NADH kinase Pos5.
Mitochondrial NADH kinase, Pos5p, is required for efficient iron-sulfur cluster biogenesis in Saccharomyces cerevisiae
Title: Mitochondrial NADH kinase, Pos5p, is required for efficient iron-sulfur cluster biogenesis in Saccharomyces cerevisiae.
NAD kinase homologues, especially Pos5p, were critical for supplying NADP and then NADPH in peroxisomal matrix. NADP, which was supplied mainly by Utr1p, Pos5p and Yef1p.
Title: [The effect of NAD kinase homologues on the beta-oxidation of unsaturated fatty acids with the double bond at an even position in Saccharomyces cerevisiae].
there are two sources of mitochondrial NADPH in yeast: one is the mitochondrial Pos5p-NADH kinase reaction and the other is the mitochondrial Pos5p-NAD kinase reaction followed by the mitochondrial NADP(+)-dependent acetaldehyde dehydrogenase reaction.
Title: Two sources of mitochondrial NADPH in the yeast Saccharomyces cerevisiae.
POS5, the mitochondrial NADH kinase enzyme, has been genetically characterized/
Title: Genomic characterization of POS5, the Saccharomyces cerevisiae mitochondrial NADH kinase.
Utr1 and Pos5 are responsible for essentially all NAD/NADH kinase activity in vivo
Title: Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD+ kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ kinase activity	IEA Inferred from Electronic Annotation more info
enables NADH kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADH kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info