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    CTI6 Cti6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855920, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CTI6
    Gene description
    Cti6p
    Primary source
    FungiDB:YPL181W
    Locus tag
    YPL181W
    See related
    SGD:S000006102; AllianceGenome:SGD:S000006102; VEuPathDB:YPL181W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RXT1
    Summary
    Enables methylated histone binding activity. Involved in negative regulation of heterochromatin assembly and regulation of cellular macromolecule biosynthetic process. Part of Rpd3L complex. Orthologous to human PHF20 (PHD finger protein 20) and PHF20L1 (PHD finger protein 20 like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CTI6 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (203421..204941)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative mitochondrial 54S ribosomal protein RTC6 Neighboring gene Rtt10p Neighboring gene Tco89p Neighboring gene protein-serine/threonine phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae. Puig S, et al. J Biol Chem, 2004 Jul 16. PMID 15133041
    2. Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1. Aref R, et al. Curr Genet, 2020 Dec. PMID 32980916, Free PMC Article
    3. The phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-dependent Tup1 conversion (PIPTC) regulates metabolic reprogramming from glycolysis to gluconeogenesis. Han BK, et al. J Biol Chem, 2013 Jul 12. PMID 23733183, Free PMC Article
    4. Single-cell analysis reveals that noncoding RNAs contribute to clonal heterogeneity by modulating transcription factor recruitment. Bumgarner SL, et al. Mol Cell, 2012 Feb 24. PMID 22264825, Free PMC Article
    5. Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Knott SR, et al. Genes Dev, 2009 May 1. PMID 19417103, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
      Title: Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
    2. Transcription in the absence of heme required the presence of Cti6p to overcome the effect of Tup1p, and Cti6p was recruited to the ARN1 promoter in the absence of heme.
      Title: Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of rDNA heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of silent mating-type cassette heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L complex HDA PubMed 
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex HDA PubMed 
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cti6p
    NP_015144.1
    • Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      203421..204941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183995.1 → NP_015144.1  TPA: Cti6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I7, Q08923, Q6B1X3
      UniProtKB/TrEMBL
      A0A8H4BVX5, A6ZW72, B3LKP7, C7GJD0, G2WP01, N1NVN9
      Conserved Domains (1) summary
      cd15550
      Location:74 → 120
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08923.1

    Gene LinkOut

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