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    CBC2 nuclear cap-binding protein subunit CBC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855925, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CBC2
    Official Full Name
    nuclear cap-binding protein subunit CBC2
    Primary source
    SGD:S000006099
    Locus tag
    YPL178W
    See related
    AllianceGenome:SGD:S000006099; FungiDB:YPL178W; VEuPathDB:YPL178W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CBP20; MUD13; SAE1
    Summary
    Enables RNA cap binding activity. Involved in mRNA splicing, via spliceosome. Part of commitment complex and nuclear cap binding activity complex. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CBC2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (212158..212784)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein-serine/threonine phosphatase Neighboring gene tRNA-Glu Neighboring gene Cup9p Neighboring gene Tre1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Lewis JD, et al. Nucleic Acids Res, 1996 Sep 1. PMID 8811086, Free PMC Article
    2. T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export. Dower K, et al. RNA, 2002 May. PMID 12022234, Free PMC Article
    3. The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. Colot HV, et al. Genes Dev, 1996 Jul 1. PMID 8682299
    4. Yeast hnRNP-related proteins contribute to the maintenance of telomeres. Lee-Soety JY, et al. Biochem Biophys Res Commun, 2012 Sep 14. PMID 22902537, Free PMC Article
    5. 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. Shen EC, et al. J Biol Chem, 2000 Aug 4. PMID 10823828

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Npl3 and Cbc2 may function in maintaining telomere stability perhaps as telomere capping proteins.
      Title: Yeast hnRNP-related proteins contribute to the maintenance of telomeres.
    2. CBC2 is a governor of gene-specific pre-mRNA splicing during meiotic development.
      Title: Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of commitment complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear cap binding complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear cap binding complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear cap-binding protein subunit CBC2
    NP_015147.1
    • Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      212158..212784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183992.1 → NP_015147.1  TPA: nuclear cap-binding protein subunit CBC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3J0, Q08920
      UniProtKB/TrEMBL
      A6ZW75, B3LKQ0, B5VSZ4, C7GJC7, C8ZIK0, G2WP04, N1NY09
      Conserved Domains (2) summary
      COG0724
      Location:1 → 159
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:48 → 125
      RRM_NCBP2; RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08920.1

    Gene LinkOut

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