U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    COX10 protoheme IX farnesyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855931, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    COX10
    Official Full Name
    protoheme IX farnesyltransferase
    Primary source
    SGD:S000006093
    Locus tag
    YPL172C
    See related
    AllianceGenome:SGD:S000006093; FungiDB:YPL172C; VEuPathDB:YPL172C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protoheme IX farnesyltransferase activity. Involved in heme A biosynthetic process. Located in mitochondrion. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease and mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See COX10 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (224353..225741, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nip100p Neighboring gene mitochondrial 54S ribosomal protein YmL40 Neighboring gene NADPH dehydrogenase Neighboring gene Dap1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. COX10 codes for a protein homologous to the ORF1 product of Paracoccus denitrificans and is required for the synthesis of yeast cytochrome oxidase. Nobrega MP, et al. J Biol Chem, 1990 Aug 25. PMID 2167310
    2. Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3. Tzagoloff A, et al. EMBO J, 1990 Sep. PMID 2167832, Free PMC Article
    3. Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals. Moraes CT, et al. Biochim Biophys Acta, 2004 Dec 6. PMID 15576047
    4. The biosynthesis of heme O and heme A is not regulated by copper. Morrison MS, et al. Biochemistry, 2005 Sep 20. PMID 16156667
    5. Reaction of S. cerevisiae mitochondria with ligands: Kinetics of CO and O(2) binding to flavohemoglobin and cytochrome c oxidase. Björck ML, et al. Biochim Biophys Acta Bioenerg, 2017 Feb. PMID 27871795

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. presence of the D336V mutation in the yeast Cox10 backbone results in a catalytically inactive enzyme that is fully competent to oligomerize
      Title: Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.
    2. The mutant Cox10 complex has enhanced efficiency in the addition of heme a to Cox1.
      Title: The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.
    3. COX10, the physiological partner of COX15, does not share the same regulatory mechanism with COX15
      Title: Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protoheme IX farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protoheme IX farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protoheme IX farnesyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heme O biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protoheme IX farnesyltransferase
    NP_015153.1
    • Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      224353..225741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183986.1 → NP_015153.1  TPA: protoheme IX farnesyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3J6, P21592
      UniProtKB/TrEMBL
      B3LKQ6, B5VSZ9, C7GJC3
      Conserved Domains (1) summary
      TIGR01473
      Location:147 → 442
      cyoE_ctaB; protoheme IX farnesyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21592.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous