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    ABP140 tRNA(Thr) (cytosine(32)-N(3))-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854414, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ABP140
    Official Full Name
    tRNA(Thr) (cytosine(32)-N(3))-methyltransferase
    Primary source
    SGD:S000005765
    Locus tag
    YOR239W
    See related
    AllianceGenome:SGD:S000005765; FungiDB:YOR239W; VEuPathDB:YOR239W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TRM140; YOR240W
    Summary
    Enables actin filament binding activity; protein-macromolecule adaptor activity; and tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Located in actin filament and actin filament bundle. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ABP140 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (784857..786744)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein related protein HES1 Neighboring gene uncharacterized protein Neighboring gene tetrahydrofolate synthase Neighboring gene Ssp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. F-actin dynamics in Neurospora crassa. Berepiki A, et al. Eukaryot Cell, 2010 Apr. PMID 20139238, Free PMC Article
    2. Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chan CT, et al. Chem Res Toxicol, 2015 May 18. PMID 25772370, Free PMC Article
    3. Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae. Asakura T, et al. Oncogene, 1998 Jan 8. PMID 9467951
    4. Actin cable dynamics in budding yeast. Yang HC, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11805329, Free PMC Article
    5. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. D'Silva S, et al. RNA, 2011 Jun. PMID 21518804, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.
      Title: S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.
    2. a model of translational coupling was proposed, in which ABP140 mRNA is tethered to actin cables via its nascent protein product and is transported to the distal pole by actin retrograde flow. [review]
      Title: Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae.
    3. Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae
      Title: Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
    4. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop
      Title: A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (cytidine-3-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (cytidine-3-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 

    General protein information

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    Preferred Names
    tRNA(Thr) (cytosine(32)-N(3))-methyltransferase
    NP_014882.4
    • AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      784857..786744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183658.6 → NP_014882.4  TPA: tRNA(Thr) (cytosine(32)-N(3))-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014882.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2U2, Q08641, Q08644
      UniProtKB/TrEMBL
      A6ZP79
      Conserved Domains (2) summary
      TIGR00927
      Location:53 → 247
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam08242
      Location:438 → 543
      Methyltransf_12; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08641.3

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