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    DFG16 Dfg16p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854195, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DFG16
    Official Full Name
    Dfg16p
    Primary source
    SGD:S000005556
    Locus tag
    YOR030W
    See related
    AllianceGenome:SGD:S000005556; FungiDB:YOR030W; VEuPathDB:YOR030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ECM41; ZRG12
    Summary
    Involved in protein processing and pseudohyphal growth. Located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See DFG16 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (386825..388684)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Cin5p Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Hms1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane. Obara K, et al. Cell Struct Funct, 2020 Jan 11. PMID 31787665, Free PMC Article
    2. The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition: INSIGHTS INTO SENSING MECHANISMS FOR PLASMA MEMBRANE LIPID ASYMMETRY. Nishino K, et al. J Biol Chem, 2015 Dec 25. PMID 26527678, Free PMC Article
    3. Membrane protein Rim21 plays a central role in sensing ambient pH in Saccharomyces cerevisiae. Obara K, et al. J Biol Chem, 2012 Nov 9. PMID 23019326, Free PMC Article
    4. Relationship of DFG16 to the Rim101p pH response pathway in Saccharomyces cerevisiae and Candida albicans. Barwell KJ, et al. Eukaryot Cell, 2005 May. PMID 15879523, Free PMC Article
    5. Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology. Voordeckers K, et al. Mol Microbiol, 2012 Oct. PMID 22882838, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An S. cerevisiae dfg16Delta mutant expresses Rim101p-repressed genes at elevated levels.
      Title: Relationship of DFG16 to the Rim101p pH response pathway in Saccharomyces cerevisiae and Candida albicans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dfg16p
    NP_014673.1
    • Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      386825..388684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183449.1 → NP_014673.1  TPA: Dfg16p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W295, Q99234
      UniProtKB/TrEMBL
      A6ZNN3, B3LJ83, C7GLF9, C8ZHZ0, G2WMR0, N1NVR0
      Conserved Domains (1) summary
      pfam08733
      Location:86 → 459
      PalH; PalH/RIM21
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99234.1

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