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    ERP4 Erp4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854181, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ERP4
    Official Full Name
    Erp4p
    Primary source
    SGD:S000005542
    Locus tag
    YOR016C
    See related
    AllianceGenome:SGD:S000005542; FungiDB:YOR016C; VEuPathDB:YOR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Orthologous to several human genes including TMED1 (transmembrane p24 trafficking protein 1) and TMED5 (transmembrane p24 trafficking protein 5). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ERP4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (360461..361084, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2A regulatory subunit RTS1 Neighboring gene uncharacterized protein Neighboring gene Pet127p Neighboring gene Rod1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Marzioch M, et al. Mol Biol Cell, 1999 Jun. PMID 10359606, Free PMC Article
    2. The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Springer S, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10737764, Free PMC Article
    3. Isoform-selective oligomer formation of Saccharomyces cerevisiae p24 family proteins. Hirata R, et al. J Biol Chem, 2013 Dec 27. PMID 24217251, Free PMC Article
    4. Transcriptional divergence plays a role in the rewiring of protein interaction networks after gene duplication. Gagnon-Arsenault I, et al. J Proteomics, 2013 Apr 9. PMID 23063722
    5. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Erp4p
    NP_014659.1
    • Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      360461..361084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183435.1 → NP_014659.1  TPA: Erp4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W282, Q12450
      UniProtKB/TrEMBL
      A6ZNM0, B3LJ70, B5VRR8, C7GLE6, G2WMP6, N1NVQ7
      Conserved Domains (1) summary
      pfam01105
      Location:29 → 199
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12450.1

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