MIM1 Mim1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MIM1
Gene description: Mim1p
Primary source: FungiDB:YOL026C
Locus tag: YOL026C
See related: SGD:S000005386; AllianceGenome:SGD:S000005386; VEuPathDB:YOL026C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TOM13
Summary: Involved in mitochondrial outer membrane translocase complex assembly and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MIM1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (274012..274353, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings indicate that the Saccharomyces cerevisiae Mim1/Mim2 and the Trypanosoma brucei pATOM36 are the products of convergent evolution and arose only after the ancestors of fungi and trypanosomatids diverged.
Title: Independent evolution of functionally exchangeable mitochondrial outer membrane import complexes.
The mitochondrial import component Mim1 forms a channel in the outer mitochondrial membrane that is predicted to have an alpha-helical structure for protein import.
Title: Identification of new channels by systematic analysis of the mitochondrial outer membrane.
Tom70 and Djp1 are crucial players in the biogenesis of Mim1.
Title: The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein.
The multifunctional outer membrane protein mitochondrial import 1 (Mim1) plays a central role in mediating the insertion of Ugo1.
Title: Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway.
mitochondria lacking the mitochondrial import protein 1 are impaired in the biogenesis of multispanning outer membrane proteins, whereas overexpression of Mim1 stimulates their import.
Title: The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins.
Cocrystallization of Ist1NTD with a Did2 fragment shows that Ist1 interacts with the Did2 C-terminal MIM1 (MIT-interacting motif 1) via a novel MIM-binding structural motif.
Title: Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis.
Data Show taht Mim1 plays an important role in the efficient assembly of the mitochondrial TOM complex.
Title: Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors.
These data show that the homo-oligomerization of Mim1 allows it to fulfil its function in promoting the integration of Tom20 into the mitochondrial outer membrane.
Title: Mim1 functions in an oligomeric form to facilitate the integration of Tom20 into the mitochondrial outer membrane.
Study shows that the transmembrane segment of Tom20 contains critical residues essential for docking the Tom20 receptor into its correct environment within the TOM complex; the docking reaction is catalyzed by the unique assembly factor Mim1/Tom13.
Title: The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex.
Mim1 has a vital and specific function in the assembly of the translocase of the outer mitochondrial membrane
Title: Mim1, a protein required for the assembly of the TOM complex of mitochondria.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial outer membrane translocase complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial outer membrane translocase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mim1p

NP_014616.1

Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex