EFM6 putative protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: EFM6
Official Full Name: putative protein-lysine N-methyltransferase
Primary source: SGD:S000004969
Locus tag: YNL024C
See related: AllianceGenome:SGD:S000004969; FungiDB:YNL024C; VEuPathDB:YNL024C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and protein methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Located in cytoplasm. Orthologous to several human genes including METTL21A (methyltransferase 21A, HSPA lysine) and VCPKMT (valosin containing protein lysine methyltransferase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See EFM6 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (587107..587847, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identified most known oxygen-regulated genes and also uncovered new regulated genes. Reverse transcription-quantitative PCR (RT-qPCR) analysis confirmed that the lysine methyltransferase EFM6 and the recombinase DMC1, both conserved in humans, are indeed oxygen-responsive.
Title: Time-Course Analysis of Gene Expression During the Saccharomyces cerevisiae Hypoxic Response.
Ynl024c is the enzyme responsible for methylation of eEF1A at Lys390, and in accordance with prior naming of similar enzymes, we suggest that Ynl024c is renamed to Efm6 (Elongation factor MTase 6).
Title: Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-17d12 (e-PCR)
- UniSTS:257343

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative protein-lysine N-methyltransferase

NP_014374.1

Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

587107..587847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182863.1 → NP_014374.1 TPA: putative protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014374.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1F5, P53970

UniProtKB/TrEMBL

A6ZS50, B3LNP1, B5VR13, C7GWP1, C8ZFK0, G2WM75, N1NY28

Conserved Domains (1) summary

pfam10294
Location:33 → 218

Methyltransf_16; Lysine methyltransferase