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    MTQ1 S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855662, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MTQ1
    Official Full Name
    S-adenosylmethionine-dependent methyltransferase
    Primary source
    SGD:S000005007
    Locus tag
    YNL063W
    See related
    AllianceGenome:SGD:S000005007; FungiDB:YNL063W; VEuPathDB:YNL063W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in translational readthrough. Located in mitochondrion. Orthologous to human HEMK1 (HemK methyltransferase family member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MTQ1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (507758..508702)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Aqr1p Neighboring gene type I HSP40 co-chaperone YDJ1 Neighboring gene tRNA 1-methyladenosine methyltransferase subunit GCD10 Neighboring gene rRNA (cytosine-C5-)-methyltransferase NOP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the hemK gene product involvement in protoporphyrinogen oxidase activity in yeast. Le Guen L, et al. FEMS Microbiol Lett, 1999 Apr 1. PMID 10220893
    2. The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p. Polevoda B, et al. J Biol Chem, 2006 Feb 3. PMID 16321977
    3. The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome. Hillman GA, et al. J Biol Chem, 2019 Jun 21. PMID 31053642, Free PMC Article
    4. Genome-wide bimolecular fluorescence complementation analysis of SUMO interactome in yeast. Sung MK, et al. Genome Res, 2013 Apr. PMID 23403034, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-(glutamine-N5) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational readthrough IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine-dependent methyltransferase
    NP_014336.1
    • S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      507758..508702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182901.1 → NP_014336.1  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1B7, P53944
      UniProtKB/TrEMBL
      B3LNS2, C7GLU0, C8ZGG6, N1P4I0
      Conserved Domains (1) summary
      TIGR00536
      Location:1 → 283
      hemK_fam; HemK family putative methylases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53944.1

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