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    POL2 DNA polymerase epsilon catalytic subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855459, updated on 28-Oct-2024

    Summary

    Official Symbol
    POL2
    Official Full Name
    DNA polymerase epsilon catalytic subunit
    Primary source
    SGD:S000005206
    Locus tag
    YNL262W
    See related
    AllianceGenome:SGD:S000005206; FungiDB:YNL262W; VEuPathDB:YNL262W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DUN2
    Summary
    Enables SUMO binding activity; catalytic activity, acting on DNA; and single-stranded DNA binding activity. Contributes to double-stranded DNA binding activity. Involved in DNA metabolic process; mitotic DNA integrity checkpoint signaling; and mitotic sister chromatid cohesion. Located in replication fork. Part of epsilon DNA polymerase complex. Used to study cancer (multiple) and pleomorphic xanthoastrocytoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); endometrial cancer (multiple); lung cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See POL2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (148212..154880)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transporter Neighboring gene protein transporter YIF1 Neighboring gene origin recognition complex subunit 5 Neighboring gene ribosome biosynthesis protein LTO1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables SUMO binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA 3'-5' DNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication proofreading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication proofreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in base-excision repair, gap-filling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gene conversion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leading strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic intra-S DNA damage checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide-excision repair, DNA gap filling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of epsilon DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of epsilon DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA polymerase epsilon catalytic subunit
    NP_014137.1
    • Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      148212..154880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183100.1NP_014137.1  TPA: DNA polymerase epsilon catalytic subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014137.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0T1, P21951
      UniProtKB/TrEMBL
      A6ZRI1
      Conserved Domains (4) summary
      cd05779
      Location:283486
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:5451166
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
      pfam03104
      Location:121442
      DNA_pol_B_exo1; DNA polymerase family B, exonuclease domain
      pfam08490
      Location:15281920
      DUF1744; Domain of unknown function (DUF1744)