UBP15 ubiquitin-specific protease UBP15 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UBP15
Official Full Name: ubiquitin-specific protease UBP15
Primary source: SGD:S000004920
Locus tag: YMR304W
See related: AllianceGenome:SGD:S000004920; FungiDB:YMR304W; VEuPathDB:YMR304W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cysteine-type deubiquitinase activity. Involved in free ubiquitin chain depolymerization and protein deubiquitination. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in cytosol and peroxisome. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See UBP15 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (874987..878679)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results uncover a novel function for DUBs in the endocytic pathway by which Ubp2 and Ubp15 positively regulate the ART-Rsp5 network.
Title: Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs.
Ubp15 interacts with Clb5 independent of Cdh1 and deubiquitinates Clb5 in a reconstituted system. Thus deubiquitination by Ubp15 counteracts anaphase-promoting complex activity toward cyclin Clb5 to allow Clb5 accumulation and a timely entry into S phase.
Title: The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae.
removal of ubiquitin from the PTS1 receptor Pex5p is a specific event and might represent a vital step in receptor recycling.
Title: Ubp15p, a ubiquitin hydrolase associated with the peroxisomal export machinery.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in free ubiquitin chain depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in free ubiquitin chain depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-specific protease UBP15

NP_014033.1

EC 3.4.19.12

Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiquitinated forms of Pex5p; deubiquitinates Clb5p, counteracting APC activity, and facilitating both Clb5p accumulation and S phase entry; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

874987..878679

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182814.1 → NP_014033.1 TPA: ubiquitin-specific protease UBP15 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014033.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0D1, P50101

UniProtKB/TrEMBL

C7GPV9, C8ZFH2

Conserved Domains (1) summary

COG5077
Location:1 → 1229

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]